Tafil: Uses, Dosage, Side Effects, Price, Addiction

What is Tafil used for?

Tafil is a brand of alprazolam produced by Pfizer, it is used to treat the symptoms of anxiety, panic disorder, and anxiety associated with depression. Tafil may be used alone or with other medications.

The active ingredient in Tafil (alprazolam) is a Schedule IV controlled substance, which is less likely to be abused than a Schedule III drug, but it still has the potential for abuse. The drug can become addictive, and it’s especially dangerous when prescribed along with opioids.

How Tafil works

Tafil belongs to a class of drugs called anti-anxiety agents, Anxiolytics, Benzodiazepines. It works by increasing the effects of a brain chemical called gamma-aminobutyric acid (GABA), which promotes calmness and produces a relaxed feeling. The drug decreases the level of excitement in the brain to treat anxiety and panic disorders

What form(s) does Tafil come in?

Tafil comes as a tablet, an extended-release tablet, an orally disintegrating tablet (a tablet that dissolves quickly in the mouth). The 5 variants of Tafil includes:

  • Tafil 0.25 mg tablet which contains 250 mcg alprazolam.
  • Tafil 0.5 mg tablet which contains 500 mcg alprazolam.
  • Tafil 1.0 mg tablet which contains 1 mg alprazolam.
  • Tafil 2.0 mg tablet which contains 2 mg alprazolam.
  • Tafil XR controlled-release tablets

How should I take Tafil?

A person should take Tafil by mouth as a doctor directs. The dosage will be based on the following factors:

•          why the person is taking it

•          their age

•          how their body responds to the treatment

The recommended dose of Tafil for adults also varies depending on its use. The starting dose for excessive anxiety is 0.25 mg taken 2 or 3 times a day. This is gradually increased until anxiety is controlled and side effects are minimized. Elderly patients may be started at a lower dose of 0.125 mg taken 2 or 3 times a day. The usual maximum dose is 3 mg daily.

The starting dose for panic attacks is 0.5 mg to 1 mg at bedtime or 0.5 mg taken 3 times daily. The dose is then gradually increased until there are no more panic attacks.

A doctor may gradually increase the dosage of Tafil until the drug works effectively for the person. People should closely follow their doctor’s instructions to reduce the risk of side effects.

If a person has used this medication regularly for a long time or in high dosages, withdrawal symptoms can occur if they suddenly stop taking it. To prevent this, a doctor may reduce the dosage of Tafil gradually

What happens if I miss a dose of Tafil?

If a person misses a dose of Tafil, they should take the missed dose as soon as they remember. However, they should skip the missed dose if it is almost time for their next scheduled dose. They should not take extra to make up for the missed dose.

What happens if I overdose on Tafil?

Symptoms of a Tafil overdose include:

•          tiredness

•          confusion

•          impaired coordination

•          diminished reflexes

•          coma

Death has occurred in association with overdoses of Tafil by itself, as it has with other benzodiazepines.

If an overdose of Tafil occurs, a person needs emergency medical attention. Somebody should call 911 or Poison Control at 800-222-1222.

What are the possible side effects of Tafil?

Tafil may cause serious side effects including:

•          depressed mood,

•          thoughts of suicide or hurting yourself,

•          racing thoughts,

•          increased energy,

•          unusual risk-taking behavior,

•          confusion,

•          agitation,

•          hostility,

•          hallucinations,

•          uncontrolled muscle movements,

•          tremor,

•          convulsions (seizure), and

•          pounding heartbeats or fluttering in your chest

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects of Tafil include:

•          drowsiness,

•          feeling tired,

•          slurred speech,

•          lack of balance or coordination,

•          memory problems, and

•          feeling anxious early in the morning

Tell the doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Tafil. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

What medications may interact with Tafil?

If your doctor has directed you to use Tafil, your doctor or pharmacist may already be aware of any possible drug interactions, health risks, and side effects, and may be monitoring you for them. Do not start, stop, or change the dosage of this drug or any medicine before checking with your doctor, health care provider, or pharmacist first.

Severe Interactions of Tafil include:

•          itraconazole

•          ketoconazole

•          sodium oxybate

•          tipranavir

Serious Interactions of Tafil include:

•          carbamazepine

•          cimetidine

•          clarithromycin

•          erythromycin base

•          erythromycin ethylsuccinate

•          erythromycin lactobionate

•          erythromycin stearate

•          idelalisib

•          itraconazole

•          ivacaftor

•          ketoconazole

•          nefazodone

•          rifabutin

•          rifampin

•          saquinavir

•          St. John’s wort

•          valerian

Tafil has moderate interactions with at least 264 different drugs.

Minor interactions of Tafil include:

•          brimonidine

•          ciprofloxacin

•          esomeprazole

•          eucalyptus

•          fleroxacin

•          gemifloxacin

•          green tea

•          levofloxacin

•          lithium

•          moxifloxacin

•          norfloxacin

•          ofloxacin

•          omeprazole

•          rifabutin

•          sage

•          vinpocetine

•          zolpidem

This document does not contain all possible interactions of this drug with other drugs. Therefore, before using this medication, tell your doctor or pharmacist of all the medications you use. Keep a list of all your medications with you, and share the list of drugs with your doctor and pharmacist. Check with your doctor if you have health questions or concerns.

Frequently Asked Questions about Tafil

Q: How long does it take to feel the effects of Tafil?

Tafil is taken by mouth and is readily absorbed into the bloodstream. You should start feeling the effects of Tafil in under an hour. The medication reaches peak concentrations in the bloodstream in one to two hours following ingestion.

People who take Tafil will often build up a tolerance. For these people, it may take longer to feel the sedative effects of Tafil or the sedation may not feel as strong.

Q: How long does it take for the effects of Tafil to wear off?

One way to find out how long a drug will last in the body is to measure its half-life. The half-life is the time it takes for half of the drug to be eliminated from the body.

Tafil has an average half-life of roughly 11 hours in healthy adults. In other words, it takes 11 hours for the average healthy person to eliminate half of the dose of Tafil. However, it’s important to note that everyone metabolizes medications differently, so the half-life will vary from person to person. Studies have shown that the half-life of Tafil ranges from 6.3 to 26.9 hours, depending on the person.

It takes several half-lives to fully eliminate a drug. For most people, Tafil will fully clear their body within two to four days. But you will stop “feeling” the sedative effects of Tafil before the drug has actually fully cleared your body. This is why you may be prescribed Tafil up to three times per day.

Q: How long does Tafil stay in your system?

Studies have shown that the half-life of Tafil ranges from 6.3 to 26.9 hours. It is important to realize that half-life is a figure that is an estimate of the time it takes for the concentration or amount in the body of that drug to be reduced by exactly one-half (50%). After four to five half-lives, 97% of a drug has cleared from the body, and the drug is no longer considered to be having any effect. However, this does not mean that it won’t be detectable by a drug test, as this depends on how specific and sensitive the drug test is.

If we use the average half-life of Tafil, which is 11.2 hours, then the following is estimated for a 1mg dose of Tafil:

  • 11.2 hours after administration, 0.5mg remains
  • 22.4 hours minutes after administration, 0.25mg remains
  • 33.6 hours after administration, 0.125mg remains
  • 44.8 hours after administration, 0.063mg remains
  • 56 hours after administration, 0.0315mg remains.

In theory, we can see that after 56 hours (2.3 days), almost all the original Tafil dose (slightly less than 97%) has been eliminated in people whose Tafil half-life is 11.2 hours. However, in some people, the half-life of Tafil is 26.9 hours. In these people, it will take approximately 134.5 hours (5.6 days) for almost 97% of a dose of Tafil to be eliminated.

Q: What does Tafil withdrawal feel like?

Tafil has a high potential to be a habit-forming drug. Symptoms of withdrawal typically begin two to seven days after your last dose. They can last two to eight weeks.

If you take Tafil, don’t stop it without talking to your doctor first. Some withdrawal symptoms can be dangerous. You need to follow a program with your doctor’s supervision to taper off the high doses and ultimately quit entirely.

Symptoms of withdrawal include:

•          sleep problems and insomnia

•          restlessness

•          nervousness

•          aggression

•          poor concentration

•          suicidal thoughts

•          worsened anxiety or panic attacks

•          depression

•          seizures

Your doctor can administer medication to help ease these symptoms and prevent further complications.

Can you drink alcohol while taking Tafil?

Taking Tafil with alcohol will intensify the side effects of both substances. Researchers don’t know exactly why this happens. It likely has to do with the chemical interactions between Tafil and alcohol in the body.

2018 animal study suggests the presence of ethanol, the main ingredient in alcoholic drinks, can increase the maximum concentration of alprazolam in the bloodstream.

In turn, this can cause both an enhanced high or “buzz” as well as enhanced side effects. The liver also needs to work harder, since it breaks down both alcohol and Tafil in the body.

Tafil vs Xanax which is stronger?

Tafil and Xanax both contain the same active ingredient (alprazolam) as a result, Tafil XR side effects are the same as Xanax XR side effects while Tafil 2mg is equivalent to Xanax 2mg, none is stronger than the other at the same dose.

What is the price of Tafil and Tafil XR?

The average price of Tafil 0.25 mg with a prescription is around $4.92 per tablet or $492 for a supply of 100 tablets, depending on the pharmacy you visit. Prices are for cash-paying customers only and are not valid with insurance plans.

The street price ranges between $3 to $5 for Tafil 0.25mg to 1mg and $5 for Tafil 2mg.

What is the price of Tafil pills in Mexico?

Tafil is cheaper in Mexico and can be purchased in retail pharmacies for between 700 and 800 Mexican pesos or around 15.63 United States dollars for ten tablets of 1mg Tafil.

Med safety does not recommend buying Tafil or any other brand of alprazolam from online pharmacies as they could be laced with fentanyl which can result in overdose and instant death. In a 12-month period, more than 100,000 Americans died of overdoses, up almost 30 percent from the 78,000 deaths in the prior year, according to provisional figures from the National Center for Health Statistics.


Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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