Drugs Q & A

How Long After Taking Ibuprofen Can You Drink Alcohol?

Even in small amounts, alcohol may intensify medication side effects such as sleepiness, drowsiness, and light-headedness, which may interfere with your concentration and ability to operate machinery or drive a vehicle, and lead to serious or even fatal accidents.

Because alcohol can adversely interact with hundreds of commonly used medications, it’s important to observe warning labels and ask your doctor or pharmacist if it’s safe to use alcohol with any medications and herbal remedies that you take.

What is ibuprofen?

Ibuprofen is one of many available forms of this medication. Ibuprofen belongs to a class of medications called NSAIDs. It works by stopping the body’s production of a substance that causes pain, fever, and inflammation. When taken by mouth, ibuprofen takes about 15 to 30 minutes to kick in and one to two hours to take full effect. You will start to notice decreased pain or fever reduction when ibuprofen begins to work.

Prescription ibuprofen is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). It is also used to relieve mild to moderate pain, including menstrual pain (pain that happens before or during a menstrual period).

Nonprescription ibuprofen is used to reduce fever and to relieve minor aches and pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. For strains and sprains, some doctors and pharmacists recommend waiting 48 hours before taking ibuprofen as it may slow down healing. If you are unsure, speak to your doctor or pharmacist. Ibuprofen is typically used for period pain or toothache.

Ibuprofen acts by stopping the creation of certain prostaglandins, which are lipids that deal with injury or illness and are active in the pathways that control inflammation, pain, and fever. Ibuprofen inhibits the action of cyclooxygenase, which is necessary for prostaglandin creation. Ibuprofen is not selective and COX-2 prostaglandins are responsible for the desired analgesic and antipyretic effects.

What is the recommended dosage of Ibuprofen?

It is generally advised that you use ibuprofen exactly as directed on the label, or as prescribed by your doctor. Use the lowest dose that is effective in treating your condition. An ibuprofen overdose can damage your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Take ibuprofen 800 mg with food or milk to lessen stomach upset. Adults over 60 years old should take as little ibuprofen as possible to manage their symptoms. Older adults have a higher risk of kidney and gastrointestinal side effects.

Can I take ibuprofen and alcohol together?

No, you should avoid taking alcohol and ibuprofen together as they both can irritate the lining of the stomach and intestines. Mixing the two can cause side effects that vary in severity from mild to serious depending on the dose and how much alcohol a person ingests.

How long after taking ibuprofen can you drink alcohol?

Generally, it takes one hour for each unit of alcohol to leave your body – this means if you had eight pints of ordinary strength beer and stopped drinking at midnight, all of the alcohol would not be dispelled from your body (and you would not be safe to drive) until about 4 pm the following day.

Your body size will also determine how long alcohol stays in your system or how quickly it is eliminated. Ideally, you should wait for at least 24 hours (a day) after taking alcohol before you take ibuprofen. If you have taken a large quantity of alcohol, allow more time at least 48 hours (two days or more) before you start taking ibuprofen.

What are the possible side effects of Ibuprofen?

The more common side effects of ibuprofen are:

•          constipation

•          diarrhea.

•          gas

•          heartburn

•          nausea

•          stomach pain

•          vomiting

Not everyone has these side effects. When they do occur, the effects are usually mild. Many people can prevent these side effects by taking ibuprofen with milk or food.

Serious side effects of ibuprofen

Serious side effects can also occur. Most of these risks are uncommon and can usually be avoided by taking ibuprofen as recommended.

However, taking too much ibuprofen or taking it for too long can make these serious side effects more likely.

Heart attack and stroke

For most people, the risks of heart attack and stroke are rare. However, your risks increase if you use too much ibuprofen or use it for too long. Your risk is also higher if you:

•          have other risk factors for heart attack or stroke

•          have a clotting disorder

•          take other medications that affect how your blood clots

If you have any risk factors or take other drugs, talk to your doctor before using ibuprofen.

Decreased kidney function and increased blood pressure

Prostaglandins help keep the pressure in your kidneys at the right level to filter the fluids in your body and maintain your blood pressure.

Ibuprofen changes your body’s production of prostaglandins. This change can lead to an imbalance in your body fluid pressure, which can decrease your kidney function and increase your blood pressure.

Symptoms of decreased kidney function include:

•          increased blood pressure

•          fluid buildup

•          dehydration

•          urinating less frequently

•          dizziness

Your risk is increased if you:

•          are an older adult

•          have kidney disease

•          take blood pressure medications.

Ulcers and bleeding in the stomach and intestine

Prostaglandins also help maintain the constant repair of your stomach lining, which protects you from damage from stomach acid.

Because ibuprofen decreases how much prostaglandin you make, stomach damage such as bleeding and ulcers in the stomach and intestines is a possible side effect.

This side effect is fairly rare. However, the risk increases the longer you use ibuprofen. Other factors that increase your risk include:

•          a history of ulcers or bleeding in your stomach or intestines

•          older age

•          use of oral steroids or blood thinners also known as anticoagulants

•          smoking

•          alcohol use, specifically more than three alcoholic beverages per day

If you have severe stomach pain or you notice bloody or tarry stools, you may have symptoms of an ulcer. Contact your doctor right away and stop taking ibuprofen.

Allergic reaction

Some people have an allergic reaction to ibuprofen, but this is also rare.

If you’ve had allergic reactions to aspirin, don’t take ibuprofen. If you start to have trouble breathing or your face or throat starts to swell, contact your doctor right away and stop taking ibuprofen.

Liver failure

There’s a very rare risk of liver failure after taking ibuprofen. If you have liver disease, talk to your doctor before taking ibuprofen. Stop taking ibuprofen and contact your doctor right away if you start to have any of the following symptoms:

•          flu-like symptoms.

•          itchiness

•          lack of energy

•          nausea

•          pain in the upper right area of your abdomen

•          tiredness

•          yellowing of your skin or the whites of your eyes

These may be signs of liver damage or liver failure.

Ibuprofen can be a safe and easy over-the-counter remedy (OTC) for minor aches and pains. However, if you don’t use it as recommended, ibuprofen can possibly be harmful.

It’s always smart to talk to your doctor before taking ibuprofen if you’re not sure if you should use it. If you experience bothersome side effects or believe you may have taken too much, contact your doctor right away.

Most of the serious side effects result from taking the drug when you shouldn’t, taking too much of it, or taking it for too long. You can reduce your risk of side effects by using the smallest possible dose for the shortest possible time.


Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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