Drugs Q & A

Is Ibuprofen (Advil) A Blood Thinner?

What are blood thinners?

A blood thinner is a substances that reduce the blood’s ability to form clots. Blood clotting is a necessary process, but sometimes the blood can clot too much, leading to complications that can be potentially dangerous. People who have certain medical conditions, such as congenital heart defects, may require blood-thinning medications to reduce their risk of heart attack or stroke.

Blood thinners have been around since the mid-1900s. Although the name is misleading — they do not actually “thin” the blood — like earlier stated, they effectively prevent blood clots from forming in patients at high risk for diseases of the heart and blood vessels. Blood thinners can also lead to serious, potentially life-threatening bleeding.

What is ibuprofen?

Ibuprofen is a commonly used nonsteroidal anti-inflammatory (NSAID) drug which is available both by prescription and over-the-counter. Ibuprofen is considered to be among the safest NSAIDs and is generally well tolerated but can, nevertheless, rarely cause clinically apparent and serious acute liver injury.

Ibuprofen was discovered in 1961 by Stewart Adams and John Nicholson while working at Boots UK Limited and initially marketed as Brufen. It is available under a number of trade names, including Nurofen, Advil and Motrin. It was first marketed in 1969 in the United Kingdom and in 1974 in the United States.

Is ibuprofen (Advil) a blood thinner?

Yes, ibuprofen is considered a blood thinner because it slows down your blood clotting time. For example, if you cut yourself or have an injury where you bleed, it may take longer for you to form a blood clot.

According to drugs.com, the risk of stomach bleeding and a stomach ulcer may also be increased if you are at risk, take prednisone or other corticosteroids, smoke or drink alcohol regularly, or take other medicines that also increase your risk of bleeding.

Tell your doctor if you take any of the following medications: anticoagulants (‘blood thinners’) such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ketoprofen and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking ibuprofen and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body’s response to ibuprofen. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with prescription ibuprofen and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer’s website to obtain the Medication Guide.

Always have a drug interaction check performed any time you start or stop a medication. If you notice signs or symptoms of bleeding, such as red or black-colored or tarry stools, vomit that is bright red blood or looks like coffee grounds, severe stomach pain, anemia, severe headache, low blood pressure, shortness of breath, and weakness, contact your doctor immediately.

You can also find useful information on: Can I Take Expired Ibuprofen?

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Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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