According to the American Medical Association (AMA) Manual of Style, the definitive guide on medical writing and style, dose and dosage each have very specific meanings. A dose refers to a specified amount of medication taken at one time. By contrast, the dosage is the prescribed administration of a specific amount, number, and frequency of doses over a specific period of time.
In other words, a dose is simply an amount (think weight) of a medication that is administered at one specific time. Whereas, the dosage is the dose, or amount of drug, attached to a time-frequency. A dosage guides a drug regimen.
What is Gen-Payne Capsule?
Gen-Payne Capsule is a combination analgesic containing the following active ingredients; paracetamol, codeine and ibuprofen. Studies have shown that combining paracetamol and other NSAIDs could give a theoretical synergistic analgesic effect according to already known or assumed mechanisms of action. Synergism is defined as an additive or supra-additive effect not achieved by one of the drugs alone.
NSAIDs, such as ibuprofen, have analgesic, antipyretic and anti-inflammatory actions. They inhibit synthesis of prostaglandins by inhibiting cyclo-oxygenase (COX), present as COX-1 and COX-2. Their analgesic and anti-inflammatory effects are a consequence of COX-2 inhibition.
Despite its widespread use, the mode of action of paracetamol is yet to be fully determined, although a centrally mediated analgesic action is thought likely. Paracetamol has minimal anti-inflammatory activity, implying a different mode of action from that of NSAIDs.
Codeine belongs to a class of medications called opiate (narcotic) analgesics and to a class of medications called antitussives. When codeine is used to treat pain, it works by changing the way the brain and nervous system respond to pain.
The combination of 3 analgesics with different modes of action results in an additive rather than a synergistic effect; the efficacy of the combination in acute pain is roughly similar to the sum of the efficacies of individual agents.
What is Gen-Payne Capsule used for?
Gen-Payne Capsule is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
- Menstruation pain
- Back pain
- Pain in teeth
- Muscles pain
- Joint pain
- Pain in body
How many Gen Payne Capsule can you take?
For treatment of mild to moderate pain with or without fever, 1-2 capsules of Gen-payne is taken every 4 hours. Users have reported thrice a day and twice a day as the most common frequency of using Gen-Payne capsule. Please follow your doctor’s advice on how often you need to use Gen-Payne capsule. Do not exceed 12 capsules in 2 hours. This medication contains ibuprofen, excess ibuprofen can cause serious nervous system problems such as seizures (neurotoxicity), low blood pressure (hypotension), low temperature (hypothermia), and other severe metabolic problems.
You should not take if:
- Your doctor has advised you not to
- You are allergic to codeine
- You are not able to take the paracetamol or ibuprofen provided with the medication
- You need to do anything other than sleep for the next four hours.
- You may be tested for drugs of abuse.
How long should I take Gen-payne Capsules?
If you have bought combined ibuprofen, paracetamol and codeine from a pharmacy, do not use it for more than 3 days. If you still have pain, talk to your pharmacist or doctor. It’s important to ask them for advice about ongoing pain relief.