Pregnancy Warnings

Is Canex V cream Safe For Use During Pregnancy?

What is Canex V Cream?

Canex V cream is a brand of clotrimazole for use in the vagina. Clotrimazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection. In terms of pharmacological action, clotrimazole is very similar to miconazole.

This cream has a broad spectrum of antifungal activity. It is effective with respect to dermatophytes, and it also has an antimicrobial effect against streptococci and staphylococci. Canex V cream is used for treatment in adults and children 12 years of age and older.

Is it safe to use clotrimazole in pregnancy?

Canex V cream is generally considered safe for pregnant women to use. If you are using the pessary to treat vaginal thrush during pregnancy it is recommended that you insert it with your fingers rather than with the applicator provided.

It is very common for pregnant women to suffer from thrush. If you think you have thrush it is best to consult your doctor or midwife who will advise you as to whether treatment is recommended.

Can using Canex V cream in pregnancy cause my baby to be born with birth defects?

A baby’s body and most internal organs are formed during the first 12 weeks of pregnancy. It is mainly during this time that some medicines are known to cause birth defects. There is no scientific proof that using Canex V cream during early pregnancy increases the risk of having a baby with a birth defect. Four studies that include a total of over 5,700 pregnant women have all shown that women who used Canex V cream during early pregnancy were no more likely to have a baby with a birth defect than women who didn’t use Canex V cream.

Can using Canex V cream in pregnancy cause miscarriage?

There is no scientific proof that Canex V cream use during early pregnancy causes miscarriage. Two studies of miscarriage have been carried out, and while one showed no increased risk with Canex V cream use, the other showed a slightly increased risk. However, women using Canex V cream in pregnancy may be more likely to be obese or to have diabetes, because these factors make women more prone to thrush. Being obese or diabetic is also known to increase a woman’s chance of having a miscarriage. It is therefore possible that these factors, and not the Canex V cream treatment, explain the slightly increased risk of miscarriage seen in the one study. More research is needed before firm conclusions can be drawn.

Can using Canex V cream in pregnancy cause preterm birth or my baby to be small at birth (low birth weight)?

There is no scientific evidence to suggest Canex V cream use during pregnancy causes women to give birth earlier or have a baby with a low birth weight (less than 2,500g).

A number of studies have looked at this, and in fact, some of these have shown that women who were treated with Canex V cream during pregnancy were less likely to have a premature baby (born before 37 weeks of pregnancy), and as a consequence, were also less likely to have a low birth weight baby.

Can using Canex V cream in pregnancy cause stillbirth?

No link between Canex V cream use in pregnancy and stillbirth is known about, however no scientific studies have been carried out that have specifically investigated this.

Can using Canex V cream in pregnancy cause learning or behavioural problems in the child?

A baby’s brain continues to develop right up until the end of pregnancy. It is therefore possible that taking certain medicines at any stage of pregnancy could have a lasting effect on a child’s learning or behaviour.

No studies have investigated learning and behaviour in children whose mothers used Canex V cream in pregnancy.

Will my baby need extra monitoring during pregnancy?

Using Canex V cream during pregnancy is not expected to cause any problems that would require extra monitoring of your baby.

Are there any risks to my baby if the father has used Canex V cream?

We would not expect any increased risk to your baby if its father used Canex V cream before or around the time you became pregnant.


Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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