Duromine is a brand of Phentermine, a prescription weight loss medication approved by the FDA in 1959 for short-term use of up to 12 weeks for people older than 16. Duromine is a controlled substance due to its chemical similarities to the stimulant amphetamine making it available only with a prescription. Phentermine belongs to a class of drugs called “anorectics,” also known as appetite suppressants. Taking Duromine helps suppress your appetite, thereby limiting how many calories you eat. Over time, this can lead to weight loss.
While the exact mechanisms behind the appetite-reducing effects of Duromine remain unclear, the drug is thought to act by increasing neurotransmitter levels in your brain. Neurotransmitters are your body’s chemical messengers and include norepinephrine, serotonin, and dopamine. When your levels of these three chemicals increase, your feeling of hunger decreases.
However, you may build a tolerance to the appetite-suppressing effects of phentermine within a few weeks. In that case, you should not increase your dose of the drug but stop using it altogether.
Before taking this medicine
You should not use phentermine if you are allergic to it, or if you have:
- a history of heart disease (coronary artery disease, heart rhythm problems, congestive heart failure, stroke);
- severe or uncontrolled high blood pressure;
- overactive thyroid;
- extreme agitation or nervousness;
- a history of drug abuse; or
- if you take other diet pills.
Do not use Duromine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Weight loss during pregnancy can harm an unborn baby, even if you are overweight. Do not use Duromine if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
You should not breast-feed while using this medicine.
To make sure this medicine is safe for you, tell your doctor if you have:
- heart disease or coronary artery disease;
- a heart valve disorder;
- high blood pressure;
- diabetes (your diabetes medication dose may need to be adjusted); or
- kidney disease.
Duromine is not approved for use by anyone younger than 16 years old.
How should I take Duromine?
Take Duromine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Doses are normally taken before breakfast, or 1 to 2 hours after breakfast. Follow your doctor’s dosing instructions very carefully. Never use Duromine in larger amounts, or for longer than prescribed. Taking more of this medication will not make it more effective and can cause serious, life-threatening side effects.
This medicine is for short-term use only. The effects of appetite suppression may wear off after a few weeks.
Duromine may be habit-forming. Misuse can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.
Call your doctor at once if you think this medicine is not working as well, or if you have not lost at least 4 pounds within 4 weeks.
Do not stop using this medicine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
If you forget to take it
If you forget to take your Duromine dose at breakfast take it no later than lunchtime. Alternatively, skip the dose you missed and take your next dose at the normal time on the next day. If you take Duromine any later than lunch-time you may have trouble sleeping at night.
Never take a double dose to make up for a dose you have missed.
How Long Does Duromine Stay in Your Blood, Urine, and Hair?
The exact time is not mentioned but after taking Duromine dosage, you can detect it by a blood test for up to 24 hours. You can detect phentermine from the urine test after 1-4 days. The particular type of test is done (SAMSHA 5-Panel’s Amphetamine Test).
If you have trouble remembering when to take your medicine, ask your pharmacist for some hints.
What are the side effects of Duromine?
Tell your doctor or pharmacist as soon as possible if you do not feel well while taking Duromine.
This medicine helps most people with a weight problem but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.
Do not be alarmed by the following lists of side effects. You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor immediately or go to Accident and Emergency at your nearest hospital if you experience:
- heart attack
- myocardial infarction
The above list includes very serious side effects. You may need urgent medical attention or hospitalization. These side effects are rare.
Tell your doctor or pharmacist if you notice any of the following and they worry you:
- feeling more awake than usual
- trouble sleeping
- your heart seems to beat faster and harder
- your blood pressure may be raised slightly
- irregular heart beats
- chest pain
- feeling restless
- feelings of extreme happiness followed by depression and tiredness
- tremor (shaking)
- diarrhoea or constipation
- stomach cramps
Tell your doctor as soon as possible if you notice any of the following:
- sudden or rapid weight loss
- difficulty breathing
- chest pain
- swelling of the lower limbs
- or if you cannot exercise as much as you usually can
- dry mouth or an unpleasant taste in your mouth
- difficulty passing urine
- skin rashes
- changes in sexual drive
- swelling of the face
Tell your doctor or pharmacist if you notice anything that is making you feel unwell. Other side effects not listed above may also occur in some people.
Duromine Safety Information
Do not use Duromine if you are pregnant or breast-feeding a baby.
You should not use Duromine if you have glaucoma, overactive thyroid, severe heart problems, uncontrolled high blood pressure, advanced coronary artery disease, extreme agitation, or a history of drug abuse.
Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. A dangerous drug interaction could occur.