Sentis: Uses, How it works, Dosage, Side Effects, Interaction, Abuse

What is Sentis?

Sentis is a brand of phentermine hydrochloride, a medication used for the short-term (up to 12 weeks for people older than 16) treatment of exogenous obesity or simple obesity which is the result of maladjustments between food and exercise.

Sentis is used in combination with diet to reduce body weight, based on exercise, modification of eating habits, and calorie restriction, Sentis is a stimulant and is available if you have a prescription. Because taking Sentis comes with a risk of dependence, it is considered a controlled substance. It’s chemically similar to the stimulant amphetamine, which is also a controlled substance.

A healthcare professional may prescribe Sentis if you have obesity or (BMI) of 30 or greater in the presence of risk factors such as hypertension, diabetes, and hyperlipidemia.

Each capsule of Sentis contains phentermine hydrochloride 37.5 mg as the active ingredient.

How it works

Sentis contains phentermine and the exact mechanism of how it works and helps suppress appetite is unclear. Researchers suggest the drug increases neurotransmitter levels in the brain, which decreases hunger. Neurotransmitters the chemicals norepinephrine, serotonin, and dopamine are your body’s chemical messengers.

Weight loss results may also depend on the person’s overall changes to their diet and lifestyle. This includes regular exercise, calorie restriction, and a healthy diet.

These changes alone are often enough to cause weight loss, though Sentis may enhance these effects. For example, a study in Obesity notes that medications like Sentis may boost the efforts of some diet programs. This research notes that people who replaced one meal per day to reduce their calorie intake lost weight. And those who added phentermine to their program lost more weight and had fewer cravings.


How should I take Sentis?

Take Sentis exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

The recommended dosage of Sentis capsule for obesity in adults is 15 to 37.5 mg taken by mouth in 1 to 2 divided doses. Doses are normally taken before breakfast, or 1 to 2 hours after breakfast. Follow your doctor’s dosing instructions very carefully.

Never use Sentis in larger amounts, or for longer than prescribed. Taking more of this medication will not make it more effective and can cause serious, life-threatening side effects.

This medicine is for short-term use only. The effects of appetite suppression may wear off after a few weeks.

Sentis may be habit-forming. Misuse can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.

Call your doctor at once if you think this medicine is not working as well, or if you have not lost at least 4 pounds within 4 weeks.

Do not stop using this medicine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

What are the side effects of Sentis?

Sentis may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

•          headache

•          dizziness

•          numbness, burning or tingling in the hands, feet, face, or mouth

•          decreased sense of touch or ability to feel the sensation

•          difficulty concentrating, thinking, paying attention, speaking, or remembering

•          excessive tiredness

•          dry mouth

•          unusual thirst

•          changes or decreased ability to taste food

•          diarrhea

•          constipation

•          heartburn

•          painful menstrual periods

•          pain in the back, neck, muscles, arms or legs

•          tightening of the muscles

•          painful, difficult, or frequent urination

•          hair loss

Some side effects of Sentis can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

•          racing or a pounding heartbeat that lasts several minutes

•          sudden decrease in vision

•          eye pain or redness

•          fast, shallow breathing

•          severe pain in the pack or side

•          blood in urine

•          rash or blisters, especially if you also have a fever

•          hives

Sentis may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

What medication can interact with Sentis?

Several medications can interact with Sentis, you should avoid taking Sentis with the following drugs:

MAO inhibitors examples include isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, and tranylcypromine. Do not use this medicine and an MAO inhibitor (MAOI) within 14 days of each other.

Sentis may also interact with amantadine, American ginseng, desmopressin, eucalyptus, guarana, sage, and yerba mate.


•        Sentis is not right for everyone. Do not use it if you have an allergic reaction to phentermine or similar medicines, or if you are pregnant.

•        While taking this medication, your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

•        It is not safe to take Sentis during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

•        Do not take Sentis if you are breastfeeding, or if you have kidney disease, diabetes, glaucoma, congestive heart failure, heart or blood vessel disease, high blood pressure, overactive thyroid, or a history of stroke or drug abuse.

•        Tell your doctor if you have allergies to aspirin or tartrazine.

If tolerance to Sentis’s effects build, does Sentis quit working after a period of time?

Yes, just as tolerance to side effects builds up, most participants also experience the development of tolerance to the appetite suppressant effects of phentermine over time. To a large extent, this tolerance development can be compensated for by gradual titration of the medication dose upwards, usually by adding a second dose in the early afternoon to continue to provide good all-day appetite control. As titration of the dose too soon or at an inappropriate rate can bring back the occurrence of unpleasant side effects, this dose titration should only be done under a physician’s guidance.

Is buying Sentis over the internet recommended?

No, The FDA warns against buying medications over the internet, especially from foreign countries because the sale and distribution of medicines outside the U.S. in most cases do not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.

If you are buying Sentis, Axcion, or other brands of phentermine from a reputable source in the U.S., such as CVS, Walgreens or Walmart that requires your doctor’s prescription, you can probably safely assume that you are getting a legitimate product.

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