Drugs Q & A

Does Prednisone Cause Constipation?

Constipation is a condition in which a person has uncomfortable or infrequent bowel movements. Generally, a person is considered to be constipated when bowel movements result in the passage of small amounts of hard, dry stool, usually fewer than three times a week. However, normal stool elimination may consist of having a bowel movement three times a day or three times a week; it depends on the person.

About 4 million people in the United States have frequent constipation. Constipation is the most common gastrointestinal complaint, resulting in 2.5 million doctor visits annually.

 Hard, dry stools are the result of the colon absorbing too much water. Normally, as food moves through the colon (also known as the large intestine) the colon absorbs water while forming stool (waste products). Muscle contractions then push the stool toward the rectum, and, by the time the stool reaches the rectum, most of the water has been absorbed, making the stool solid.

When the colon’s muscle contractions are slow or sluggish, the stool moves through the colon too slowly, resulting in too much water being absorbed.

What is Prednisone?

Prednisone is used alone or with other medications to treat the symptoms of low corticosteroid levels (lack of certain substances that are usually produced by the body and are needed for normal body functioning). Prednisone is also used to treat other conditions in patients with normal corticosteroid levels. These conditions include certain types of arthritis; severe allergic reactions; multiple sclerosis (a disease in which the nerves do not function properly); lupus (a disease in which the body attacks many of its own organs); and certain conditions that affect the lungs, skin, eyes, kidneys blood, thyroid, stomach, and intestines. Prednisone is also sometimes used to treat the symptoms of certain types of cancer.

How Prednisone works

Prednisone is in a class of medications called corticosteroids. It works to treat patients with low levels of corticosteroids by replacing steroids that are normally produced naturally by the body. It works to treat other conditions by reducing swelling and redness and by changing the way the immune system works. This action blocks chemicals that normally cause inflammation as part of your body’s immune response, and can help decrease inflammation in many parts of your body.

Does Prednisone Cause Constipation?

Yes, prednisone can cause constipation, especially in older adults. Many people taking prednisone report having bowel movements too infrequently (typically fewer than three times a week); having hard or small, lumpy stools; having stools that are hard to pass; straining; having painful bowel movements; or having the sensation of incomplete emptying after a bowel movement. In studies involving high-dose prednisone, abdominal discomfort was reported among 26.8% of the patients.

The good news is that if you have mild prednisone-induced constipation, simple lifestyle changes can help manage the condition. Prevention tips include:

•          Increasing your fiber intake: Fiber-rich foods, such as fruits, vegetables and whole grains, all help improve gut function. If you have bowel sensitivity, you’ll want to avoid high-fructose fruits, such as apples, pears and watermelon, which can cause gas.

•          Getting more exercise: Regular exercise can help keep stool moving through the colon.

•          Drinking more water: Aim for eight glasses daily, and avoid caffeine, as it can be dehydrating.

•          Go when you feel like it: When you feel the urge to go, don’t wait.

When to See a Doctor About Constipation

If increasing fiber intake, exercise and hydration don’t solve the problem, your constipation may be characterized as chronic. Depending on the cause of chronic constipation, you may need physical therapy or even low-dose laxatives to treat the problem.

For chronic constipation, it’s important to meet with a professional who can help guide you to the right kind of therapy. This is especially important if you have any warning signs of disease, such as weight loss, bleeding or pain, or stools that become pencil-thin and stay that way.

All things considered, you should see a doctor if constipation or any other physical discomfort is interfering with your daily life.

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Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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