Flexiver Compuesto: Uses, Benefits, Dosage, Side Effects, Interactions

What is Flexiver Compuesto?

Flexiver Compuesto is a fixed-dose combination medication containing meloxicam and methocarbamol as active ingredients. This medication is specifically crafted to provide relief to individuals suffering from various conditions causing discomfort and limited mobility. Understanding its composition, indications, contraindications, and potential effects is crucial for informed and safe usage.

Meloxicam, a nonsteroidal anti-inflammatory drug (NSAID), serves as one of the key components in Flexiver Compuesto. NSAIDs are renowned for their ability to alleviate pain and reduce inflammation by inhibiting the production of certain chemicals in the body responsible for these sensations. By targeting the root causes of discomfort, Meloxicam aids in relieving symptoms associated with conditions like arthritis, osteoarthritis, and other musculoskeletal disorders. Its inclusion in Flexiver Compuesto underscores the medication’s focus on combating inflammation and the resulting pain.

Complementing Meloxicam, Methocarbamol plays a pivotal role in the formulation’s efficacy. Methocarbamol belongs to a class of drugs known as muscle relaxants, which act on the central nervous system to alleviate muscle spasms and tension. By exerting its effects directly on muscle fibers, Methocarbamol helps reduce stiffness and discomfort, promoting relaxation and improved mobility. This synergistic combination of Meloxicam and Methocarbamol in Flexiver Compuesto addresses both the inflammatory and muscular aspects of pain, offering comprehensive relief to individuals dealing with various painful conditions.

This medication is available in two capsule formulations namely; Meloxicam 15mg / Methocarbamol  215mg and the Meloxicam 7.5mg / Methocarbamol  215mg formulation


Flexiver Compuesto is commonly prescribed by doctors for the treatment of various conditions, particularly those associated with musculoskeletal pain and inflammation. The dosage and timing of Flexiver Compuesto can vary depending on the specific condition being treated, as well as individual patient factors such as age, weight, and medical history. It’s crucial to follow your doctor’s instructions carefully when taking this medication. Here’s an expanded overview of the dosage and timing for Flexiver Compuesto based on different conditions:

1.        Osteoarthritis: For osteoarthritis, the typical dosage of Flexiver Compuesto is often one tablet taken orally twice a day, preferably with meals. However, your doctor may adjust this dosage based on the severity of your symptoms and your response to the medication. It’s essential to take Flexiver Compuesto regularly as prescribed to maintain its effectiveness in managing osteoarthritis pain and inflammation.

2.        Rheumatoid Arthritis: In the case of rheumatoid arthritis, the dosage of Flexiver Compuesto may be similar to that for osteoarthritis, typically one tablet taken orally twice daily. However, some patients with more severe symptoms may require higher doses or additional medications in conjunction with Flexiver Compuesto to adequately control inflammation and joint damage. Your doctor will determine the most appropriate dosage and timing based on your individual needs.

3.        Acute Musculoskeletal Pain: When treating acute musculoskeletal pain, such as strains, sprains, or muscle spasms, your doctor may prescribe Flexiver Compuesto at a higher dosage for a short duration to help alleviate pain and inflammation. This may involve taking one or two tablets orally every 6 to 8 hours as needed for pain relief. It’s essential to follow your doctor’s instructions carefully and not exceed the recommended dosage or duration of treatment to avoid potential side effects.

4.        Chronic Back Pain: Chronic back pain, whether due to conditions like herniated discs or spinal stenosis, may also be managed with Flexiver Compuesto. The dosage and timing in this case would typically align with the regimen for osteoarthritis or rheumatoid arthritis, with one tablet taken orally twice daily. Your doctor may also recommend additional therapies such as physical therapy or lifestyle modifications to complement the medication’s effects.

5.        Other Conditions: Flexiver Compuesto may also be prescribed for other conditions involving musculoskeletal pain and inflammation, such as fibromyalgia or ankylosing spondylitis. In these cases, the dosage and timing may vary based on the specific needs of the patient and the severity of the condition. It’s essential to consult with your doctor for personalized recommendations tailored to your medical history and symptoms.

Regardless of the condition being treated, it’s important to take Flexiver Compuesto exactly as prescribed by your doctor. Do not adjust the dosage or timing without consulting your healthcare provider, and be sure to report any side effects or concerns promptly.


There have been no reported teratogenic (causing birth defects) or mutagenic (causing genetic mutations) effects associated with Flexiver Compuesto. However, its use is not recommended during pregnancy. Meloxicam, one of the active ingredients in Flexiver Compuesto, is categorized as Category C according to the FDA. Category C indicates that there are potential risks to the fetus based on animal studies, but there are limited human studies available. Due to the potential risks to the developing fetus, healthcare providers typically advise against using Flexiver Compuesto during pregnancy unless the potential benefits outweigh the risks, and alternative treatments are not suitable.


The use of Flexiver Compuesto is not recommended while breastfeeding. There is a possibility that the active ingredients, methocarbamol and meloxicam, could be excreted into breast milk. It’s important to consider the potential risks to the infant, including adverse effects or exposure to medication components that could affect their development or health. If treatment with Flexiver Compuesto is deemed necessary for a breastfeeding mother, it’s crucial to discuss the risks and benefits with a healthcare provider. They may recommend closely monitoring the infant for any adverse effects or considering alternative treatments.

Side Effects

Adverse reactions associated with the Flexiver Compuesto can vary in frequency and severity. Some of the common adverse reactions include:

1.        Gastrointestinal Symptoms: These are the most frequent adverse reactions and may include dyspepsia (indigestion), nausea, diarrhea, abdominal pain, vomiting, constipation, and flatulence (excessive gas).

2.        Central Nervous System Effects: Lightheadedness, drowsiness, and dizziness can occur, which may impair mental and/or physical abilities. Blurred vision, headache, and fever are also possible adverse effects.

3.        Skin Reactions: Itching and skin rash may develop as a hypersensitivity reaction to the medication.

4.        Hematological Effects: Anemia (reduced red blood cell count) may occur in some cases.

5.        Edema: Swelling or fluid retention, leading to edema, may occur as a result of the medication’s effects on fluid balance in the body.

It’s important for patients to be aware of these potential adverse reactions and to report any unusual or severe symptoms to their healthcare provider promptly. In some cases, the benefits of taking Flexiver Compuesto may outweigh the risks of experiencing these adverse reactions, but close monitoring and communication with a healthcare professional are essential for managing any potential side effects effectively.

Flexiver Compuesto Contraindications

1.        Hypersensitivity: Patients with a known hypersensitivity to the active ingredients or any component of the formula should not use Flexiver Compuesto.

2.        Cross-sensitivity: There is a risk of cross-sensitivity with acetylsalicylic acid (ASA) and other NSAIDs. Therefore, Flexiver Compuesto should not be prescribed to patients with a history of previous administration of these drugs that resulted in manifestations of asthma, angioedema, or urticaria.

3.        Alcohol: Combining Flexiver Compuesto with alcohol is contraindicated due to the potential for central nervous system (CNS) depression.

4.        Peptic ulcer: The use of Flexiver Compuesto is not recommended in cases of active peptic ulcer or severe gastrointestinal hemorrhage (IH) or renal insufficiency (IR).

Flexiver Compuesto Warnings and Precautions

1.        Gastrointestinal Conditions: Patients with a history of acid-peptic illness or those currently under treatment with anticoagulants should be cautious when using Flexiver Compuesto.

2.        Special Populations: Elderly patients, as well as those with congestive heart failure (CHF), liver cirrhosis, nephrotic syndrome, or preexisting renal failure, should be monitored closely while using Flexiver Compuesto.

3.        Renal Function: Patients undergoing major surgical procedures who are at risk of hypovolemia should be monitored closely as they are more sensitive to the inhibition of renal prostaglandin synthesis by NSAIDs like Flexiver Compuesto. Monitoring of urinary volume and kidney function should commence at the start of treatment.

These contraindications, warnings, and precautions are important considerations for healthcare providers when prescribing Flexiver Compuesto to patients. It’s essential to adhere to these guidelines to minimize the risk of adverse effects and ensure the safe and effective use of the medication.


Do not take Flexiver Compuesto with the following medications:

1.        Other NSAIDs: Concurrent use of Flexiver Compuesto with other nonsteroidal anti-inflammatory drugs (NSAIDs) is contraindicated due to the increased risk of gastrointestinal bleeding and other adverse effects.

2.        Anticoagulants: Both oral and parenteral anticoagulants should not be taken with Flexiver Compuesto as they may increase the risk of bleeding due to the antiplatelet effects of NSAIDs.

3.        Lithium: Concurrent use of Flexiver Compuesto and lithium should be avoided as NSAIDs may increase lithium levels in the blood, leading to potential toxicity.

4.        Methotrexate: Methotrexate and Flexiver Compuesto should not be used together due to the potential for increased methotrexate toxicity, including hematologic and gastrointestinal adverse effects.

5.        Beta Blockers and ACE Inhibitors: Concurrent use of Flexiver Compuesto with beta-blockers and ACE inhibitors may diminish the antihypertensive effects of these medications and increase the risk of renal impairment.

Interactions with Alcohol

•          Use of alcohol with Flexiver Compuesto may cause central nervous system (CNS) depression. Therefore, it is recommended to avoid alcohol while taking this medication to prevent potential adverse effects such as drowsiness, dizziness, and impaired coordination.

It’s essential for patients to inform their healthcare provider about all medications, supplements, and substances they are taking before starting Flexiver Compuesto to avoid potential interactions and ensure the safe and effective use of the medication


Joan David-Leonhard

Joan David Leonhard is a recent Pharm.D graduate with a strong passion for the pharmaceutical industry and a particular interest in pharmaceutical media and communication. Her brief internship experience includes roles in pharmacy where she built strong patient-pharmacist relationships and a pharmaceutical media internship where she actively contributed to drug information articles, blog posts, social media engagement, and various media projects.
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