Cuerpo amarillo fuerte; Uses, Benefits, Dosage, Side Effects, Warnings  

What is Cuerpo amarillo fuerte?

Cuerpo amarillo fuerte is a Mexican brand of progesterone injection utilized for various medical purposes related to hormonal imbalances in the body. Primarily, this injection is employed in the treatment of uterine bleeding resulting from hormonal irregularities. This condition, often disruptive and uncomfortable for affected individuals, can be effectively managed through the administration of progesterone injections. Additionally, these injections are prescribed for females who experience irregular or absent monthly menstrual cycles, aiding in the regulation of their reproductive health.

It’s important to note that progesterone injections may also be recommended for other therapeutic reasons, tailored to individual patient needs. However, it is crucial for patients to engage in thorough discussions with their healthcare providers to understand the specific rationale behind their prescription and the anticipated benefits.

It is imperative for patients using progesterone injections to be mindful of potential interactions and contraindications. Notably, combining estrogens with a progestin-like progesterone injection for the purpose of preventing heart disease or dementia is cautioned against. Research suggests that such combinations may heighten the risk of adverse health outcomes, including heart attacks, strokes, breast cancer, blood clots, or dementia. Therefore, patients are advised to exercise caution and adhere to medical guidance regarding the use of estrogens, with or without progestin, ensuring that they are employed for the shortest duration necessary and at the lowest effective dosage.

What do I need to tell my doctor BEFORE I take Cuerpo amarillo fuerte?

•          If you have an allergy to progesterone or any other part of progesterone injection.

•          If you are allergic to progesterone injection; any part of progesterone injection; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

•          If you have had any of these health problems: Bleeding disorder; blood clots or risk of having a blood clot; breast cancer or other cancer; liver disease; heart attack; stroke; or tumor where estrogen or progesterone make it grow.

•          If you have unexplained vaginal bleeding.

•          If you have had a recent miscarriage.

This is not a list of all drugs or health problems that interact with progesterone injection.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take progesterone injection with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Cuerpo amarillo fuerte?

•          Tell all of your healthcare providers that you take progesterone injections. This includes your doctors, nurses, pharmacists, and dentists.

•          Avoid driving and doing other tasks or actions that call for you to be alert until you see how progesterone injection affects you.

•          If you have an allergy to any type of nuts or seeds, talk with your doctor.

•          If you have high blood sugar (diabetes), talk with your doctor. This medicine may raise blood sugar.

•          Be sure to have regular breast exams and gynecology check-ups. You will also need to do breast self-exams as you have been told.

•          This medicine may affect certain lab tests. Tell all of your healthcare providers and lab workers that you take progesterone injections.

•          Blood clots have happened with progesterone injection. These clots have included heart attack, stroke, and clots in the leg, lung, or eye. Sometimes blood clots can be deadly. Tell your doctor if you have ever had a blood clot. Talk with your doctor.

•          Talk with your doctor if you will need to be still for long periods of time like long trips, bedrest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.

•          If you are 65 or older, use progesterone injection with care. You could have more side effects.

•          This medicine is not approved for use in children. Talk with the doctor.

•          This medicine may stop you from having a period (menstrual bleeding) for some time. This is not a method of birth control.

•          A type of pneumonia has happened with progesterone injection. Call your doctor right away if you have shortness of breath or other trouble breathing, cough, or fever.

•          Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is this medicine (Cuerpo amarillo fuerte) best taken?

Proper administration of Cuerpo amarillo fuerte is essential for its effectiveness and safety. Here’s how this medicine is best taken:

  1. Follow Doctor’s Orders: Use progesterone injection exactly as directed by your doctor. It’s important to carefully read all the information provided to you and follow all instructions closely.
  2. Administration Technique: The injection is typically administered into a muscle. If you are responsible for administering the shot yourself, your doctor or nurse will provide thorough instructions on the proper technique.
  3. Hand Hygiene: Before and after use, ensure to wash your hands thoroughly to maintain cleanliness and minimize the risk of contamination.
  4. Visual Inspection: Prior to use, examine the solution carefully. Do not use the injection if the solution appears cloudy or contains visible particles. Similarly, if there are any changes in color, refrain from using it and consult your healthcare provider.
  5. Safe Disposal: After use, dispose of needles safely in a designated needle/sharp disposal box. It is crucial not to reuse needles or any other items associated with the injection process. When the disposal box is full, adhere to local regulations for its proper disposal. If you have any uncertainties regarding disposal procedures, consult a doctor or pharmacist for guidance.

For Parenteral Route Administration:

  • Intramuscular (IM) Injection: Choose an appropriate area such as the quadriceps femoris of the left or right thigh. Clean the selected area with cotton, then administer a deep injection at a 90º angle. It is recommended to inject the product slowly to minimize local tissue damage.
  • Subcutaneous (SC) Injection: Select a suitable area such as the front of the thigh or lower abdomen. Cleanse the area with cotton, then firmly pinch the skin and insert the needle at an angle of 45º to 90º. As with the IM injection, inject the product slowly to minimize local tissue damage.

By adhering to these guidelines for proper administration, patients can optimize the therapeutic benefits of Cuerpo amarillo fuerte or any progesterone injection while minimizing potential risks and ensuring their safety and efficacy.

What are some other side effects of Cuerpo amarillo fuerte?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

•          Back, muscle, or joint pain.

•          Bloating.

•          Diarrhea or constipation.

•          Enlarged breasts.

•          Feeling dizzy, sleepy, tired, or weak.

•          Hair growth.

•          Hair loss.

•          Headache.

•          Irritation where progesterone injection is used.

•          Lowered interest in sex.

•          More hungry.

•          Pimples (acne).

•          Stomach pain or cramps.

•          Tender breasts.

•          Trouble sleeping.

•          Upset stomach or throwing up.

•          Vaginal bleeding or spotting.

•          Weight gain or loss.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.


Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

•          Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

•          Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

•          Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.

•          Shortness of breath, a big weight gain, or swelling in the arms or legs.

•          Trouble walking.

•          Very bad dizziness or passing out.

•          Eyesight changes or loss, bulging eyes, or change in how contact lenses feel.

•          A lump in the breast, breast pain or soreness, or nipple discharge.

•          Vaginal itching or discharge.

•          Vaginal bleeding that is not normal.

•          Pain when passing urine.

•          Passing urine more often.

•          Depression or other mood changes.

•          Memory problems or loss.

•          Seizures.

•          Flushing.

•          Fast or abnormal heartbeat.

•          This medicine may cause you to swell or keep fluid in your body. Tell your doctor if you have swelling, weight gain, or trouble breathing.

•          Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.


Interactions with progesterone can significantly affect its effectiveness and may lead to potential complications. Here are some important interactions to be aware of:

  1. Concomitant Use with Other Intravaginal Therapies: When Cuerpo amarillo fuerte is used concurrently with other intravaginal therapies, there is a potential for interaction. It’s crucial to consult with a healthcare provider to ensure the safe and effective use of these medications together, as their combined effects may lead to adverse reactions or diminished efficacy.
  2. Decreased Bioavailability with Cytochrome P4503A4 Enzyme Inducers: Certain medications, such as rifampicin, carbamazepine, griseofulvin, phenobarbital, phenytoin, or Hypericum perforatum (St. John’s Wort), are known to induce the cytochrome P4503A4 enzyme. When Cuerpo amarillo fuerte is taken concomitantly with these inducers, there may be a reduction in its bioavailability, potentially compromising its therapeutic effects. Close monitoring and dosage adjustments may be necessary when these medications are used together.
  3. Increased Bioavailability with Cytochrome P4503A4 Enzyme Inhibitors: Conversely, medications that inhibit the cytochrome P4503A4 enzyme can lead to increased bioavailability of Cuerpo amarillo fuerte e. This heightened bioavailability may potentiate the effects of progesterone, increasing the risk of adverse reactions or toxicity. Healthcare providers should exercise caution and consider dosage adjustments when progesterone is administered alongside enzyme inhibitors to avoid potential complications.

Understanding these interactions is essential for healthcare providers to make informed decisions regarding the prescription and management of Cuerpo amarillo fuerte therapy. Patients should communicate any medications they are currently taking to their healthcare provider to minimize the risk of adverse interactions and ensure the safe and effective use of progesterone.

How do I store and/or throw out Cuerpo amarillo fuerte?

•          Store at room temperature.

•          Store in a dry place. Do not store in a bathroom.

•          Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.

•          Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.


Joan David-Leonhard

Joan David Leonhard is a recent Pharm.D graduate with a strong passion for the pharmaceutical industry and a particular interest in pharmaceutical media and communication. Her brief internship experience includes roles in pharmacy where she built strong patient-pharmacist relationships and a pharmaceutical media internship where she actively contributed to drug information articles, blog posts, social media engagement, and various media projects.
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