Top 18 Signs That You Need Hormone Replacement Therapy

Menopause is the time that marks the end of your menstrual cycles. It’s diagnosed after you’ve gone 12 months without a menstrual period. Menopause can happen in your 40s or 50s, but the average age is 51 in the United States. Menopause is a natural biological process.

Menopause is a normal part of aging. In the years before and during menopause, the levels of female hormones can go up and down. This can cause symptoms such as hot flashes, night sweats, pain during sex, and vaginal dryness. For some women, the symptoms are mild, and they go away on their own and for others, they can be severe and cause great discomfort.

What is hormone replacement therapy (HRT)?

Hormone replacement therapy (HRT) also called menopausal hormone therapy, is a treatment to relieve symptoms of menopause. It replaces hormones that are at a lower level as you approach menopause.

HRT is not for everyone. You should not use HRT if you:

  • Think that you are pregnant
  • Have problems with vaginal bleeding
  • Have had certain kinds of cancers
  • Have had a stroke or heart attack
  • Have had blood clots
  • Have liver disease.

There are various ways of delivering hormone therapy, and the different types provide different combinations and amounts of hormones.

Common types include:

Estrogen-only HRT: A doctor may recommend this if a person has had their uterus and ovaries removed, in which case progesterone is not necessary.

Cyclical, or sequential HRT: This may be a good option if symptoms occur before menopause; the dosage can align with the menstrual cycle.

Continuous HRT: After menopause, a doctor may prescribe a continuous combination of estrogen and progesterone.

Local estrogen: Vaginal tablets, creams, or rings can help with urogenital symptoms, including vaginal dryness and irritation.

Taking HRT has some risks. For some women, hormone therapy may increase their chances of getting blood clots, heart attacks, strokes, breast cancer, and gallbladder disease. Certain types of HRT have a higher risk, and each woman’s own risks can vary, depending on her medical history and lifestyle. You and your healthcare provider need to discuss the risks and benefits for you. If you do decide to take HRT, it should be the lowest dose that helps and for the shortest time needed. You should check if you still need to take HRT every 3-6 months.

What Are The Signs That You Need Hormone Replacement Therapy?

The following are some of the signs that might indicate a need for hormone replacement therapy:

1.        Anxiety: Anxiety is a common psychological symptom that can be linked to hormonal imbalances. Fluctuations in hormones, especially estrogen and progesterone, can affect neurotransmitters in the brain, leading to mood swings, irritability, and anxiety. Hormone replacement therapy, particularly for women during menopause, can help stabilize these hormone levels, potentially reducing anxiety and improving overall mental well-being.

2.        Bladder or Urinary Problems: Bladder and urinary problems, such as incontinence, are often associated with age-related changes in the pelvic floor muscles and connective tissues. Hormonal changes can further contribute to these issues. Estrogen, in particular, helps maintain the strength and elasticity of the urethra and surrounding tissues. When estrogen levels decline, the risk of urinary problems increases. HRT can help by restoring hormonal balance and potentially alleviating these urinary issues.

3.        Brittle Bones: Osteoporosis, characterized by brittle and fragile bones, is a common concern for individuals, especially postmenopausal women. Estrogen plays a crucial role in maintaining bone density. When estrogen levels decrease, bones can become more susceptible to fractures and osteoporosis. Hormone replacement therapy can help by providing the body with the necessary estrogen to preserve bone health and reduce the risk of fractures.

4.        Decreased Sex Drive: A diminished sex drive, also known as low libido or hypoactive sexual desire disorder, can be linked to hormonal imbalances. Both men and women can experience a decline in sexual desire due to changes in testosterone levels. Hormone replacement therapy, specifically testosterone replacement for men and women, can enhance libido and sexual satisfaction.

5.        Depression: Hormonal fluctuations can significantly impact one’s mental health. For many individuals, depression can be triggered or exacerbated by hormonal changes. Women, in particular, are vulnerable to hormonal shifts during menstruation, pregnancy, and menopause, which can contribute to mood swings and depression. Hormone replacement therapy can help stabilize these fluctuations, potentially alleviating depressive symptoms.

6.        Hirsutism, or Excessive Hair Growth: Hirsutism is a condition characterized by excessive hair growth in areas where hair is typically minimal or absent, such as the face, chest, or back. It is often associated with an overproduction of androgens, which are male sex hormones. Hormone replacement therapy can address this issue by regulating androgen levels and reducing the unwanted hair growth.

7.        Hot Flashes: Hot flashes are one of the most well-known symptoms of menopause. These sudden sensations of intense heat, often accompanied by sweating and flushed skin, can be extremely uncomfortable and disruptive to daily life. Hot flashes are primarily linked to hormonal imbalances, especially decreasing estrogen levels. Hormone replacement therapy, specifically estrogen therapy, can be effective in reducing the frequency and severity of hot flashes.

8.        Insomnia: Insomnia, or difficulty sleeping, is a common symptom associated with hormonal changes. Hormonal imbalances, such as those experienced during menopause, can lead to sleep disturbances. Night sweats, anxiety, and mood swings can also contribute to insomnia. Hormone replacement therapy may help regulate hormone levels, leading to improved sleep patterns and overall restorative sleep.

9.        Irregular Periods/Spotting: Irregular or abnormal menstrual cycles and spotting can be indicative of hormonal imbalances, particularly in women. Conditions such as polycystic ovary syndrome (PCOS) and perimenopause can disrupt regular menstrual patterns. Hormone replacement therapy can help regulate these cycles by providing the necessary hormones for balance.

10.      Irritability: Mood swings and irritability are common emotional symptoms associated with hormonal fluctuations. These changes can occur at various stages of life, such as puberty, menstruation, pregnancy, and menopause. Hormone replacement therapy can help stabilize hormone levels, potentially reducing irritability and mood swings.

11.      Memory Problems: Cognitive issues, such as memory problems and difficulty concentrating, can be linked to hormonal imbalances. Estrogen, in particular, plays a role in maintaining cognitive function. Declining estrogen levels, as seen during menopause, can lead to cognitive changes. Hormone replacement therapy may help improve memory and cognitive function by restoring estrogen levels.

12.      Night Sweats: Night sweats are nocturnal episodes of excessive sweating, often associated with hot flashes. They can disrupt sleep and lead to fatigue and irritability. Hormone replacement therapy, especially estrogen therapy, may help reduce the frequency and intensity of night sweats, leading to better sleep quality.

13.      Painful Sexual Intercourse: Painful sexual intercourse, known as dyspareunia, can be a result of hormonal imbalances affecting vaginal health. Estrogen helps maintain vaginal moisture and elasticity. When estrogen levels decline, vaginal tissues can become thinner and less lubricated, leading to discomfort during intercourse. Hormone replacement therapy can help by restoring estrogen levels and alleviating this discomfort.

14.      Sleep Problems: Sleep disturbances, including insomnia and night sweats, are often related to hormonal fluctuations. Hormone replacement therapy can help regulate hormones, leading to improved sleep quality and overall restorative sleep.

15.      Thinning Hair: Thinning hair, known as hair loss or alopecia, can be associated with hormonal imbalances, especially in women. Androgenetic alopecia, a common form of hair loss, is influenced by androgens. Hormone replacement therapy can address this issue by regulating androgen levels and promoting hair growth.

16.      Vaginal Dryness: Vaginal dryness is a common issue for women experiencing hormonal changes, particularly during menopause. Estrogen helps maintain vaginal moisture and lubrication. When estrogen levels decline, vaginal dryness can occur, leading to discomfort and pain during sexual intercourse. Hormone replacement therapy can help alleviate this symptom by restoring estrogen levels and improving vaginal health.

17.      Vaginal Itching, Burning, Pain, or Discomfort: Vaginal discomfort, including itching, burning, and pain, can be a consequence of hormonal imbalances. These symptoms often occur alongside vaginal dryness and can significantly impact a woman’s quality of life. Hormone replacement therapy can address these issues by restoring hormonal balance and improving vaginal health.

18.      Weight Gain: Weight gain is a complex issue influenced by multiple factors, including hormones. Hormonal changes, such as those occurring during menopause, can lead to an increased tendency to gain weight, particularly around the abdominal area. Hormone replacement therapy can potentially help regulate hormones and mitigate some of the weight gain associated with hormonal imbalances.

What to expect during hormone replacement therapy

If you are considering HRT or have already started this treatment, it’s essential to understand what to expect during the process. Here is a general overview of what you might experience while undergoing HRT:

1.        Medical Assessment: Before starting HRT, you will typically undergo a thorough medical assessment by a healthcare provider. This assessment involves a discussion of your medical history, current health, and any symptoms you are experiencing. Your provider will also perform necessary tests to determine your hormone levels, ensuring that HRT is appropriate and safe for you.

2.        Treatment Plan: Based on your medical assessment, your healthcare provider will develop a personalized treatment plan. This plan will outline the type of hormones you need, the dosage, and the method of administration. HRT can involve various hormones, such as estrogen, progesterone, testosterone, or a combination of these, depending on your specific needs.

3.        Hormone Delivery Methods: As earlier stated, HRT can be administered in several ways, including:

a. Oral: Hormones can be taken in pill form, which is convenient but may have different absorption rates and metabolic effects.

b. Transdermal (Patch or Gel): You can apply patches or gel to your skin, allowing a slow, consistent release of hormones into your bloodstream.

c. Injections: Some hormones are administered through injections, which can be done at a medical facility or self-administered at home.

d. Vaginal (Creams, Rings, or Suppositories): Vaginal HRT products are available for conditions like vaginal dryness and discomfort.

e. Implants: Hormone pellets can be implanted under the skin, releasing hormones gradually over several months.

4.        Symptom Relief: One of the primary goals of HRT is to relieve symptoms associated with hormonal imbalances. For menopausal individuals, this can include alleviating hot flashes, night sweats, vaginal dryness, and mood swings. For those with androgen deficiency, it may involve increasing energy levels, improving muscle mass, and enhancing libido.

5.        Monitoring and Adjustments: Throughout your HRT journey, your healthcare provider will closely monitor your progress. This involves regular check-ups, hormone level testing, and discussions about your symptoms. Adjustments to your treatment plan, including hormone dosage or delivery method, may be made to optimize symptom relief and minimize side effects.

6.        Side Effects: It’s essential to be aware of potential side effects associated with HRT. These side effects can vary depending on the type of hormones used and the individual’s response. Common side effects may include:

  • Breast tenderness
  • Nausea c. Headaches
  • Mood swings
  • Weight gain or loss
  • Fluid retention
  • Changes in menstrual bleeding (for those who still have periods)

It’s important to promptly report any severe or unusual side effects to your healthcare provider.

7.        Risks and Benefits: HRT offers various benefits, such as symptom relief and improved quality of life. However, it’s not without risks. Depending on your individual health and medical history, HRT may increase the risk of certain conditions, including:

  • Breast cancer
  • Endometrial cancer (for estrogen-only HRT without a progestin)
  • Blood clots
  • Stroke
  • Heart disease

Your healthcare provider will discuss the potential risks and benefits with you, helping you make an informed decision about whether HRT is the right choice for your specific circumstances.

8.        Duration: The duration of HRT varies from person to person. Some individuals may only need it for a short time to manage specific symptoms, while others may require long-term or ongoing treatment. Your healthcare provider will guide you on the appropriate duration of HRT based on your needs and goals.

9.        Regular Follow-Up: Even after symptom relief is achieved, regular follow-up with your healthcare provider is crucial. Hormone levels and overall health will be monitored to ensure that the treatment continues to be safe and effective.

10.      Lifestyle Considerations: In addition to HRT, lifestyle factors play a significant role in maintaining hormonal balance and overall well-being. Your healthcare provider may recommend a healthy diet, regular exercise, stress management, and other lifestyle changes to complement your HRT regimen.

11.      Discontinuation: At some point, you and your healthcare provider may decide to discontinue HRT. This decision could be based on factors like symptom resolution, personal preferences, or concerns about long-term risks. The process of discontinuation is typically gradual, and your provider will guide you through it to minimize any potential side effects.

It’s important to remember that HRT is not a one-size-fits-all solution, and the experience can vary greatly from person to person. What you can expect during HRT is highly dependent on your individual circumstances, including the type of hormones used, the delivery method, and your unique medical history.

Always work closely with a knowledgeable healthcare provider who can provide guidance, monitor your progress, and make necessary adjustments to your treatment plan. Open and honest communication with your healthcare team is essential to ensure that HRT is both safe and effective in addressing your specific needs.


Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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