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The Intriguing Link Between Chronic Constipation and Cognitive Decline

Chronic constipation has long been regarded as a gastrointestinal issue, but recent preliminary research suggests that its implications may extend beyond the gut. A compelling study conducted on more than 110,000 middle-aged and older adults in the United States has raised intriguing possibilities regarding its connection to cognitive decline. The research findings, presented at a meeting of the Alzheimer’s Association in Amsterdam and online, show a potential link between chronic constipation and signs of an “older” brain. Although the study does not prove causality, it adds to the mounting evidence connecting gut health to brain health. This article delves into the findings of this study, explores the potential mechanisms underlying the gut-brain connection, and highlights the significance of further research in this area.

The Study Findings

The research team found that individuals experiencing chronic constipation, defined as having fewer than three bowel movements per week, displayed cognitive declines compared to their counterparts with regular bowel movements. These cognitive declines were equivalent to experiencing three additional years of aging. Furthermore, those with chronic constipation were 73% more likely to report waning cognitive skills. These findings are striking and prompt a deeper investigation into the possible connection between the gut and the brain.

The Gut-Brain Connection

Researchers posit that the gut-brain connection could be mediated through the gut microbiome, an intricate ecosystem of microorganisms residing in the intestines. The gut microbiome plays essential roles in various bodily functions, including nutrient absorption, immune response regulation, and even influencing brain function. The possibility of a link between gut bacteria and cognitive health has garnered significant interest in recent years, particularly in relation to degenerative brain conditions like Alzheimer’s disease.

Several studies have explored the potential links between gut microbiome profiles and different health conditions, including Alzheimer’s. For example, one study observed that individuals with early markers of Alzheimer’s exhibited gut microbiomes distinct from those of their peers. The question arises: could constipation be a symptom of a gut microbiome associated with poorer cognitive function? While this remains to be proven, the initial findings offer valuable insights into the possible role of gut health in cognitive aging.

Understanding the Relationship

Despite the compelling preliminary findings, researchers emphasize the need for further investigation to understand the complex relationship between chronic constipation and cognitive decline. Senior director of scientific programs and outreach for the Alzheimer’s Association, Claire Sexton, asserts that the study’s results do not yet clarify whether constipation itself or other factors, such as disruptions in the gut microbiome or changes in diet, drive the association between constipation and cognitive decline.

Promisingly, the Alzheimer’s Association is actively running a clinical trial that aims to investigate the effects of a healthy diet, exercise, and lifestyle measures on cognitive decline in older adults. This trial will delve into the gut-brain connection and explore whether lifestyle changes can alter gut bacteria and correlate with improvements in cognitive health.

Managing Chronic Constipation for Cognitive Health

While the direct link between constipation and cognitive decline remains uncertain, experts recommend addressing chronic constipation to improve overall gut health. Dr. Dong Wang, the senior researcher on the study, emphasizes the importance of discussing gut health, including constipation, with older patients. By encouraging individuals to consume a diet rich in fiber from vegetables, fruits, whole grains, and beans, and incorporating regular exercise into their routines, constipation can be alleviated and gut health optimized.

Importantly, these lifestyle habits have been associated with a lower risk of age-related cognitive decline and dementia, further highlighting their significance in promoting overall health and well-being. Regular exercise, in particular, has been shown to have numerous cognitive benefits, including enhanced brain function and memory retention.


The preliminary study linking chronic constipation and cognitive decline presents an intriguing avenue for further research into the gut-brain connection. While the findings do not establish causality, they offer compelling evidence for the potential impact of gut health on brain health. Understanding the mechanisms underlying this connection could pave the way for targeted interventions to promote healthy cognitive aging.

As we await more comprehensive research, it is essential for healthcare providers to discuss gut health, including constipation, with their older patients. Encouraging dietary changes that promote a healthy gut microbiome, along with regular exercise, can potentially improve cognitive health and overall well-being. By embracing a holistic approach that encompasses gut health and brain health, we can empower individuals to take proactive steps in maintaining their cognitive vitality as they age.

In conclusion, the connection between chronic constipation and cognitive decline remains a fascinating area of investigation. The gut-brain axis is a complex and dynamic system that holds great promise for understanding and potentially addressing cognitive decline in older adults. With ongoing research and clinical trials, we may soon uncover innovative strategies and medications to preserve cognitive function and improve the quality of life for aging populations.


Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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