Drugs Q & A

Does Paracetamol Cause Constipation?

What is paracetamol?

Paracetamol (Panadol, Calpol, Alvedon) is a common analgesic and antipyretic drug that is used to temporarily relieve mild-to-moderate pain and fever. It is commonly included as an ingredient in cold and flu medications and is also used on its own.

Paracetamol is exactly the same drug as acetaminophen (Tylenol). Paracetamol is the drug’s name assigned using the International Nonproprietary Name (INN) generic name system. Paracetamol is the name used for the drug in places such as Europe, Australia, New Zealand, and India. Acetaminophen is the generic name assigned using the United States Adopted Names (USAN) system. Acetaminophen is the name used in countries such as the US, Canada, and Japan. Usually, the INN and USAN generic names for a drug are the same and don’t differ between countries.

In this article, we will explore the relationship between paracetamol and constipation, looking at the available research and discussing some possible reasons why constipation might occur in people who use paracetamol.

What is Constipation?

Constipation is a common digestive problem that affects people of all ages. It is defined as having fewer than three bowel movements per week, passing hard, dry stool, and experiencing difficulty passing stool. Some people may also experience abdominal pain, bloating, and discomfort. Constipation can be caused by a variety of factors, including a lack of fiber in the diet, dehydration, lack of exercise, certain medications, and certain medical conditions.

Does Paracetamol Cause Constipation?

Yes, according to a 2007 study, chronic constipation is associated with the use of paracetamol. However, a review of the literature found no significant association between paracetamol use and constipation in adults or children. Similarly, a large prospective study of more than 30,000 women found no association between paracetamol use and constipation during pregnancy.

However, it is worth noting that constipation is a known side effect of some opioid pain medications, which are sometimes combined with paracetamol in prescription medications. Opioids can slow down the movement of stool through the intestines, leading to constipation. While paracetamol itself does not have significant opioid properties, some combination medications that include paracetamol may contain opioids, which can cause constipation.

Additionally, some people may experience constipation as a result of their underlying medical condition, rather than as a side effect of medication. For example, people with irritable bowel syndrome (IBS) or other digestive disorders may be more likely to experience constipation, regardless of whether they are taking paracetamol or other medications.

Possible Reasons for Constipation in Paracetamol Users

While paracetamol itself is unlikely to cause constipation, there are several possible reasons why some people who use paracetamol may experience constipation.

Dehydration: Dehydration is a common cause of constipation, as it can make stool harder and more difficult to pass. Paracetamol can cause dehydration as a side effect, particularly if it is taken in high doses or for an extended period of time. People who use paracetamol regularly should ensure they are drinking enough water to stay hydrated, which may help prevent constipation.

Lack of physical activity: Physical activity helps stimulate the movement of stool through the intestines, and a lack of exercise can lead to constipation. People who are taking paracetamol for pain may be less likely to engage in physical activity due to discomfort or limitations in mobility, which could contribute to constipation.

Changes in diet: Paracetamol use may lead to changes in appetite or diet, which could in turn lead to constipation. For example, some people may be less likely to eat high-fiber foods or drink enough fluids when they are experiencing pain, which could contribute to constipation.

Underlying medical conditions: As mentioned earlier, some people may be more likely to experience constipation as a result of an underlying medical condition, such as IBS or other digestive disorders. In these cases, constipation may be a symptom of the underlying condition, rather than a direct result of paracetamol use.

Other medications: While paracetamol itself is unlikely to cause constipation, it is possible that other medications a person is taking could contribute to constipation. For example, some prescription pain medications that contain opioids may cause constipation as a side effect. If a person is taking multiple medications, it is important to consider the potential interactions between them and any possible side effects.

Tips for Preventing Constipation while Taking Paracetamol

If you are taking paracetamol and are concerned about constipation, there are several things you can do to help prevent or alleviate constipation symptoms:

1.      Drink plenty of fluids: Staying hydrated is important for preventing constipation. Make sure you are drinking enough water and other fluids throughout the day.

2.      Eat a high-fiber diet: Eating a diet high in fiber can help keep stool soft and promote regular bowel movements. Foods that are high in fiber include fruits, vegetables, whole grains, and legumes.

3.      Engage in physical activity: Regular physical activity can help stimulate bowel movements and prevent constipation. Even a short walk or light exercise can help.

4.      Use laxatives if necessary: If you are experiencing constipation, over-the-counter laxatives may be helpful. However, it is important to use laxatives as directed and not to rely on them too heavily, as this can lead to dependence and other health problems.

5.      Talk to your healthcare provider: If you are experiencing persistent constipation or other digestive problems, it is important to talk to your healthcare provider. They can help identify any underlying medical conditions or medication interactions that may be contributing to your symptoms, and recommend appropriate treatment options.

Conclusion

While constipation is a common side effect of some medications, there is little evidence to suggest that paracetamol causes constipation as a direct side effect. However, there are several possible reasons why some people who use paracetamol may experience constipation, such as dehydration, lack of physical activity, changes in diet, underlying medical conditions, or interactions with other medications. By staying hydrated, eating a high-fiber diet, engaging in physical activity, and talking to their healthcare provider if necessary, people who use paracetamol can help prevent or alleviate constipation symptoms.

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Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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