Drug News

NRx Pharmaceuticals Unveils pH-Neutral IV Ketamine Formulation, HTX-100, Revolutionizing Treatment

NRx Pharmaceuticals, Inc. has made a groundbreaking announcement regarding the development of a new, proprietary formulation of intravenous (IV) ketamine, named HTX-100. This innovative formulation is a result of NRx Pharmaceuticals’ collaboration with Nephron Pharmaceuticals, a leading sterile products manufacturer. The key advancement lies in achieving a neutral pH for the ketamine formulation, unlike the acidic pH found in generic formulations. This pH-neutral formulation is expected to revolutionize ketamine administration by enabling both intravenous and subcutaneous (SQ) routes, with potential applications in insulin pump-like devices in clinical settings.

The significance of this development lies not only in enhancing the delivery of ketamine but also in addressing issues related to patient comfort and safety. Traditional acidic formulations of ketamine, developed in the 1960s primarily for battlefield use, have limitations when administered subcutaneously, potentially causing pain and skin ulcers. NRx Pharmaceuticals’ novel formulation aims to overcome these challenges, paving the way for a more patient-friendly and versatile mode of administration.

Moreover, NRx Pharmaceuticals anticipates securing patent protection, such as composition of matter or formulation patents, for this proprietary formulation. This underscores the company’s commitment to innovation and intellectual property protection, ensuring its competitive advantage in the pharmaceutical market.

HTX-100 is expected to be marketed by HOPE Therapeutics, Inc., a wholly-owned subsidiary of NRx Pharmaceuticals. This underscores NRx’s strategic approach to commercialization, leveraging its subsidiary’s expertise to bring innovative therapies to market effectively.

Dr. Jonathan Javitt, Founder, Chairman, and Chief Scientist of NRx Pharmaceuticals, expressed enthusiasm about the new formulation, highlighting its potential to modernize ketamine therapy in clinical practice. He emphasized the significance of a pH-neutral, subcutaneous form of ketamine administration, which could simplify treatment protocols and enhance patient outcomes, particularly in outpatient settings.

Overall, NRx Pharmaceuticals’ development of HTX-100 represents a significant milestone in the field of central nervous system disorders. By harnessing the potential of its NMDA platform, NRx Pharmaceuticals aims to address critical unmet needs in conditions such as suicidal bipolar depression, chronic pain, and PTSD, positioning itself as a key player in the neurotherapeutics landscape.


Joan David-Leonhard

Joan David Leonhard is a recent Pharm.D graduate with a strong passion for the pharmaceutical industry and a particular interest in pharmaceutical media and communication. Her brief internship experience includes roles in pharmacy where she built strong patient-pharmacist relationships and a pharmaceutical media internship where she actively contributed to drug information articles, blog posts, social media engagement, and various media projects.
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