How to Flush Out Phentermine From Your System

Phentermine, a popular weight loss drug, has gained prominence in recent years, attracting users from various walks of life, including celebrities. Despite its effectiveness, concerns arise when faced with a drug test. How does one flush Phentermine out of their system?

This comprehensive guide aims to address this question and equip you with essential information about Phentermine and drug testing.

Understanding Phentermine: A Brief Overview

Phentermine, a prescription medication designed for weight loss, gained approval from the Food and Drug Administration (FDA) in 1959. Initially intended for short-term use, up to 12 weeks, in individuals aged 16 and older, Phentermine underwent a shift in the 1990s. During this period, pharmaceutical companies combined Phentermine with other weight-loss drugs, creating a widely known combination referred to as fen-phen. However, due to reports of severe heart issues among users, the FDA took action by removing the other two drugs involved—fenfluramine and dexfenfluramine—from the market.

In contemporary settings, Phentermine is prescribed either independently or in combination with other medications for weight loss. Its standalone forms bear the brand names Adipex-P, Sentis, Elvenir, Obexol Lomaira, and Suprenza. Additionally, it is a key component in combination medications like Qsymia, which pairs Phentermine with another drug called topiramate.

Being a stimulant, Phentermine requires a prescription for use. Recognized as a controlled substance due to the associated risk of dependence, it shares chemical similarities with the controlled substance amphetamine, emphasizing the need for cautious administration.

Healthcare professionals may recommend Phentermine in cases of obesity, defined by a body mass index (BMI) of 30 or higher. Furthermore, individuals with excess weight and a BMI equal to or exceeding 27, coupled with at least one weight-related condition such as high blood pressure, high cholesterol, or type 2 diabetes, may also receive a prescription for Phentermine.

How to Flush Phentermine Out of Your System

How it works

Phentermine operates within the class of drugs known as anorectics, commonly referred to as appetite suppressants. The primary mechanism of action involves the suppression of appetite, consequently restricting calorie intake and facilitating weight loss. Although the precise manner in which phentermine diminishes appetite is not fully understood, it is believed to influence neurotransmitter levels in the brain.

Neurotransmitters, which encompass chemicals such as norepinephrine, serotonin, and dopamine, serve as the body’s chemical messengers. Phentermine is thought to elevate the levels of these neurotransmitters, leading to a reduction in the sensation of hunger. As norepinephrine, serotonin, and dopamine increase, the inclination to consume calories diminishes, fostering a conducive environment for weight loss.

It’s worth noting that individuals using phentermine may develop a tolerance to its appetite-suppressing effects over a few weeks. In the event of such tolerance, it is advisable to engage in a discussion with a healthcare professional to explore potential adjustments or alternative approaches to wean yourself off phentermine or maintain the efficacy of the medication.

Does Phentermine Show Up on Drug Tests?

The crucial question that individuals using Phentermine face is whether it shows up on drug tests. The answer is affirmative—it can appear on standard drug tests, including blood, oral, urine, and hair tests. While not directly sought after in routine drug testing, Phentermine, being a derivative of amphetamines, may trigger a positive result due to its association with the amphetamine compound.

How Long Does Phentermine Stay in Your System?

Understanding the duration of Phentermine in the body is pivotal for navigating drug tests. Phentermine has a half-life of approximately 24 hours. Consequently, it may take up to four days for the substance to be entirely eliminated from the body. Factors such as frequency and dosage can extend this period, requiring up to seven days for complete removal in some cases.

How to Flush Phentermine out of Your System

1. Natural Detoxification

For individuals who are light users of Phentermine, opting for natural detoxification methods can be a viable approach. Phentermine is a medication commonly prescribed for weight loss, and a natural cleanse can assist in mitigating any residual effects. Embracing a healthy lifestyle is key to this process, involving components such as a well-balanced diet rich in fruits, vegetables, and whole grains. Regular physical activity is also crucial, as exercise promotes sweating and the elimination of toxins through the skin. Adequate hydration, achieved through the consumption of water and herbal teas, supports the flushing out of toxins from the body.

This natural detoxification regimen typically spans around four days and helps the body restore its balance. However, it’s essential for individuals to consult with healthcare professionals before initiating any detoxification plan to ensure it aligns with their overall health and medical history. Additionally, those with heavier usage of Phentermine or specific health concerns may require more personalized detox strategies under the guidance of healthcare providers.

2. Accelerated Natural Detox with Toxin Rid Detox Pills

Detox pills provide an expedited solution for individuals looking to accelerate the detox process, particularly when facing imminent drug testing. These pills are formulated with specific ingredients designed to enhance the body’s natural detoxification mechanisms, facilitating the rapid elimination of toxins, including substances like Phentermine.

Unlike the natural detox process, which may take several days, detox pills claim to speed up the elimination of toxins by at least 50%. This means that users, especially those in situations where quick detoxification is crucial, may achieve a clean system in as little as two days. It’s important to note that the efficacy of detox pills can vary based on individual factors such as metabolism, usage patterns, and overall health.

Additionally, while detox pills may offer a quicker solution, their effectiveness should be carefully considered, and individuals should adhere to any usage guidelines provided by the product and consult with healthcare professionals when necessary.

3. Detox Drinks

Detox drinks provide a temporary solution for concealing the presence of substances like Phentermine, offering users a brief window to submit a clean urine sample. These drinks are formulated with various ingredients aimed at diluting or masking toxins in the urine. The effectiveness of detox drinks is generally limited to a short duration, typically around three to four hours, during which the urine appears natural and free of detectable toxins. For optimal results, users are often advised to consume the detox drink approximately 90 minutes before the scheduled drug test and to urinate multiple times during this period.

While detox drinks can be a convenient option for short-term masking, it’s crucial to recognize their temporary nature and consider individual factors such as metabolism and usage patterns. Users should exercise caution and seek guidance from healthcare professionals to make informed decisions about detox methods and their potential impact on test results.

4. Hair Follicle Detoxification

Hair drug testing presents distinct challenges, especially since drugs like Phentermine can become trapped in the hair shafts over time. The Macujo method is a popular approach for individuals seeking to cleanse their hair of drug residues. This method involves using an Aloe-based shampoo in combination with various household products to open the hair cuticles and expel toxins effectively.

The Macujo method is renowned for its efficacy in removing drug residues from the most recent 90 days of hair growth, making it particularly suitable for individuals facing hair drug tests. It’s important to note that while this method is widely discussed and used, individual results may vary, and there is no guarantee of its success.

In addition, the use of household products may impact the condition of the hair and scalp, so users should exercise caution and consider consulting with professionals before opting for the Macujo method.

5. Saliva Neutralizing Gum: Oral Clear

Saliva drug testing, known for its rapid results, poses a unique challenge for individuals facing immediate testing situations. In such scenarios, having saliva-neutralizing gum can be a strategic and temporary solution. This specialized gum is designed to neutralize saliva for a short duration, typically around 10 minutes, offering a brief window for individuals to pass an oral drug test.

The gum works by temporarily altering the composition of saliva, making it less conducive for the detection of drugs. While saliva-neutralizing gum can provide a quick and convenient way to navigate an immediate testing situation, it’s crucial for individuals to be aware of its temporary effects and consider the specific guidelines and limitations associated with its use. Additionally, for long-term solutions or in situations where comprehensive testing is involved, individuals should seek advice from healthcare professionals and explore more sustainable strategies.


Navigating a Phentermine drug test requires a strategic approach, considering factors such as the type of test, testing conditions, and the individual’s usage patterns. From natural detoxification to specialized products like Toxin Rid, synthetic urine, and detox drinks, users have an array of options to choose from. It is essential to make informed decisions, adhere to recommended guidelines, and, when necessary, seek professional advice to ensure a successful and safe outcome.


Joan David-Leonhard

Joan David Leonhard is a recent Pharm.D graduate with a strong passion for the pharmaceutical industry and a particular interest in pharmaceutical media and communication. Her brief internship experience includes roles in pharmacy where she built strong patient-pharmacist relationships and a pharmaceutical media internship where she actively contributed to drug information articles, blog posts, social media engagement, and various media projects.
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