Dexabion: Uses, Dosage, Side Effects, Interactions, Warnings

What is Dexabion used for?

Dexabion is a medication that helps with different health issues. It’s used for problems in the nerves, bones, and injuries. In nerve issues (neurology), Dexabion helps with things like pain, numbness, and muscle problems. It’s used for many conditions like sciatica, back pain, and even issues with the neck and shoulders. In bone and injury cases (orthopedics and traumatology), Dexabion is important before and after surgeries.

Dexabion demonstrates notable effectiveness in alleviating swelling, particularly at the onset of nerve problems or joint pain. Its ability to effectively address a variety of nerve disorders and musculoskeletal issues provides substantial relief and support to individuals grappling with these conditions.

What are the ingredients in Dexabion injections?

Dexabion injections contain the following key active ingredients they include:

1.        Cyanocobalamin (Vitamin B12): A crucial vitamin supporting nerve function, red blood cell formation, and DNA synthesis.

2.        Dexamethasone: A potent corticosteroid with anti-inflammatory properties, often used to alleviate inflammation and immune system responses.

3.        Dexamethasone Phosphate: A salt form of dexamethasone, enhancing its solubility for pharmaceutical formulations.

4.        Lidocaine: A local anesthetic, offering pain relief by blocking nerve signals in the body.

5.        Lidocaine Hydrochloride: The hydrochloride form of lidocaine, contributes to the anesthetic effects.

6.        Pyridoxine (Vitamin B6): Essential for protein metabolism, neurotransmitter synthesis, and red blood cell production.

7.        Thiamine (Vitamin B1): Critical for energy metabolism, nerve function, and cardiovascular health.

Dexabion is presented in a solution form, providing flexibility in administration. The formulations include:

1.        Ampoules (1 ml or 2 ml): Single or multiple ampoules in a box, catering to different dosage requirements.

2.        Vials (2 ml): Available in various quantities (2, 4), offering options for diverse medical scenarios.

3.        Vial No. I + Vial No.II: Combinations of different vials in one box, possibly indicating a multi-component administration.

4.        Double Chamber Prefilled Syringe (3 ml):      Single or multiple syringes in a box, each containing two chambers with distinct solutions.

Dexabion provides a range of presentations to accommodate diverse medical situations and patient needs. The options include different volumes of ampoules, vials, and prefilled syringes. This variety reflects the adaptability of Dexabion in addressing specific health requirements.

Dexabion Benefits

Dexabion has a range of potential benefits for individuals dealing with various health issues they include:

1.        Pain Relief and Nerve Health: Dexabion can offer relief from conditions such as neuritis, neuralgia, sciatica, facial paresis, and radiculoneuritis. Its neurology-related benefits extend to addressing myalgia, low back pain, tendonitis, and scapulohumeral syndrome, providing effective pain management and supporting overall nerve health.

2.        Musculoskeletal Support: In orthopedics and traumatology, Dexabion is particularly valuable in the pre- and post-operative phases of trauma care. It is indicated for acute neuritis and articular or extra-articular rheumatism, where the rapid reduction of inflammation is crucial. This suggests that Dexabion may contribute to improved joint health and musculoskeletal function, especially during critical periods surrounding surgeries.

3.        Inflammation Reduction: One of the key benefits of Dexabion is its potential to quickly reduce inflammation. This property is particularly relevant in acute cases of neuritis and rheumatism, providing timely relief and supporting the recovery process.

4.        Optimal Surgical Outcomes: Dexabion’s use in the pre-operative phase in traumatology suggests a potential benefit in preparing patients for surgery, possibly reducing inflammation and creating a more favorable environment for optimal surgical outcomes.

5.        Versatile Application: Dexabion’s diverse range of indications in neurology and orthopedics showcases its versatility in addressing a spectrum of health conditions. This makes it a comprehensive and potentially valuable supplement for individuals experiencing nerve-related and musculoskeletal issues.

It’s important to note that while Dexabion may offer these benefits, individual responses to the medication can vary. Patients should always consult with healthcare professionals to determine the appropriateness of Dexabion for their specific health needs and conditions.

Who should not use Dexabion

Certain individuals should avoid using this medication due to potential risks or interactions. These include:

1.        Gastric or Duodenal Ulcer: People with stomach or duodenal ulcers should avoid using Dexabion, as it may exacerbate these conditions.

2.        Generalized Fungal Infections: Individuals with widespread fungal infections should refrain from using Dexabion.

3.        Viral Infections (Chickenpox, Herpes Zoster): Those with viral infections such as chickenpox or herpes zoster should not use this medication, as it may interfere with the body’s response to these infections.

4.        Tuberculosis: Individuals with tuberculosis, a bacterial infection affecting the lungs, should avoid using Dexabion.

5.        Glaucoma: People with glaucoma, a condition characterized by increased pressure within the eye, should steer clear of this medication due to potential adverse effects on eye health.

6.        Hypersensitivity to Formula Components: Individuals who are hypersensitive or allergic to any components of the Dexabion should not use it to prevent allergic reactions.

7.        Cyanocobalamin in Early Leber Disease: Cyanocobalamin, one of the components, should not be used in individuals with early Leber disease, a hereditary optic nerve disorder.

8.        Pregnancy, Breastfeeding, and Newborns: Pregnant or breastfeeding individuals and newborns are advised to avoid using Dexabion, as its safety during these periods may not be established.

It is crucial for individuals to consult with a healthcare professional before using any medication, disclosing their medical history, ongoing health conditions, and any potential contraindications. This ensures safe and appropriate use of the medication based on individual health circumstances.


Dexabion is administered through deep intramuscular injection, with the recommended frequency being once every 24 hours. The prescribed duration of use typically spans up to five consecutive days, adhering to the specific medical requirements and the severity of the condition being treated.

Administration Procedure:

1.        Preparation of the Double Chamber Syringe:

•          Begin by taking the double chamber syringe, ensuring it is securely sealed.

•          Remove the protective tip, exposing the syringe for use.

•          Attach the appropriate needle to the syringe, ensuring a secure connection.

2.        Syringe Positioning:

•          Hold the dual-chamber syringe upright, with the needle facing upward.

•          Maintain a steady hand to facilitate the accurate pouring of the solutions.

3.        Solution Mixing:

•          Slowly depress the plunger to initiate the transfer of the red solution into the clear solution chamber.

•          Execute this process with care to ensure an even and complete mixture.

•          Shake the syringe gently until the combined solution achieves a homogeneous appearance, indicating thorough mixing.

4.        Air Removal:

•          Prior to injection, it is crucial to eliminate any air trapped within the dual-chamber syringe.

•          This can be achieved by gently depressing the plunger until any air bubbles are expelled, ensuring the syringe contains only the fully mixed solution.

5.        Injection Application:

•          Following preparation, proceed with the intramuscular injection at the recommended site.

•          Administer the medication according to the prescribed dosage and schedule.

These detailed steps provide a comprehensive guide for healthcare professionals and individuals responsible for administering Dexabion. It is imperative to strictly adhere to the prescribed dosage, administration frequency, and overall guidelines provided by medical practitioners to ensure optimal therapeutic outcomes and patient safety. Patients should seek guidance from healthcare professionals for any uncertainties regarding the administration process.

Side Effects of Dexabion

Dexabion, while generally well-tolerated, may lead to certain secondary and adverse reactions. These occurrences, though infrequent, should be considered and monitored during the course of treatment. These reactions include:

1.        Cardiac Arrhythmias: Occasionally, Dexabion use has been associated with irregular heart rhythms, known as cardiac arrhythmias.

2.        Gastric and/or Duodenal Ulcer: There have been reported cases of the development or exacerbation of gastric and/or duodenal ulcers in individuals using Dexabion.

3.        Insomnia: Some individuals may experience difficulty in sleeping or insomnia during Dexabion treatment.

4.        Psychological Effects: Dexabion use has been linked to psychological effects such as irritability, nervousness, and euphoria. In rare cases, more severe psychiatric reactions like psychosis may occur.

5.        Gastrointestinal Distress: Vomiting may occur as a side effect of Dexabion.

6.        Metabolic Effects: Dexabion may lead to metabolic changes, including hyperthyroidism and hyperglycemia.

7.        Ocular Effects: Increased intraocular pressure has been reported as an adverse reaction to Dexabion.

8.        Muscle Weakness: Some individuals may experience muscle weakness as a side effect of Dexabion.

9.        Hypersensitivity Reactions: Skin and body hypersensitivity reactions are possible, though not common.

10.      Rare Adverse Events: In rare instances, susceptible individuals may experience anaphylactic shock, adrenal suppression, or Cushing’s syndrome.

Precautions Regarding Carcinogenic, Mutagenic, Teratogenic Effects, and Fertility

In studies conducted with animals, Dexabion has not shown evidence of carcinogenicity, mutagenicity, teratogenicity, or alterations in fertility. However, it’s essential to exercise caution and closely monitor for any unforeseen effects during human use.

Patients and healthcare providers should remain vigilant for the described secondary reactions, promptly reporting any concerns to ensure appropriate management and adjustment of treatment plans. As with any medication, the benefits and potential risks of Dexabion should be carefully weighed, and its use should be guided by healthcare professionals based on individual health conditions and needs.

Drug Interactions of Dexabion

Concomitant Use Interactions: The simultaneous use of Dexabion with certain medications may lead to clinically important interactions. These include:

  • Diuretics and/or Cardiac Glycosides: Concurrent use with glucocorticoids may induce interactions.
  • Hypoglycemic Agents: Interaction with drugs used to lower blood sugar levels.
  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Potential interactions with medications for pain and inflammation.
  • Oral Anticoagulants: Interaction with blood-thinning medications.
  • Active Vaccines: Dexabion use alongside active vaccines may have implications, necessitating careful consideration.

Effectiveness Reduction with Hepatic Enzyme-Inducing Drugs: Dexabion’s effectiveness may be reduced when used concurrently with hepatic enzyme-inducing drugs such as rifampicin, ephedrine, barbiturates, phenytoin, and pidone.

Thiamine Interaction: Thiamine, a component of Dexabion, may increase the effect of neuromuscular blocking agents, although the clinical significance of this interaction is unknown.

Pyridoxal Phosphate Interaction: Pyridoxal phosphate, another component of Dexabion, may enhance the peripheral decarboxylation of levodopa, reducing its effectiveness in Parkinson’s disease treatment. Concurrent administration of carbidopa with levodopa can prevent this effect. Pyridoxine hydrochloride should not be given in doses exceeding 5 mg per day to patients receiving levodopa alone.

Vitamin B6 Antagonists and Vitamin B12 Absorption: Cycloserine and hydralazine are vitamin B6 antagonists, and the administration of pyridoxine can reduce neuronal side effects related to the use of these compounds. Additionally, the absorption of vitamin B12 in the gastrointestinal system may be reduced by the administration of various drugs, including aminoglycosides, colchicine, prolonged-release potassium preparations, aminosalicylic acid and its salts, anticonvulsants (phenytoin, phenobarbital, pidone), and excessive alcohol intake for more than two weeks.

Prednisone and Vitamin B12 Absorption: Prednisone has been reported to increase vitamin B12 absorption and intrinsic factor secretion in some patients with pernicious anemia, although the clinical significance of these observations is unknown.

Chloramphenicol Interaction: Concomitant administration of chloramphenicol and vitamin B12 may antagonize the hematopoietic response to the vitamin.

These interactions underscore the importance of close monitoring and healthcare professional guidance when using Dexabion in conjunction with other medications. Patients should inform their healthcare providers of all medications and supplements they are taking to mitigate potential risks and ensure effective treatment.

Dexabion Vs Dolo Neurobion injection

Dexabion and Dolo Neurobion are both vitamin B complex supplements, but they have some differences in their formulations and intended uses. Dexabion typically contains a combination of B vitamins, including B1, B6, and B12, and is often used to address vitamin B deficiencies and support overall health. On the other hand, Dolo Neurobion injection is a pain reliever that combines B vitamins with the analgesic (pain-relieving) properties of diclofenac. Dolo Neurobion is commonly used for the treatment of pain associated with neurologic disorders, such as neuropathy and neuralgia. Dolo Neurobion injection contains 50mg Diclofenac + 50mg Pyridoxine (vitamin B6) + 50mg Thiamin (vitamin B1) + 1mg vitamin B12.

While both supplements contain B vitamins, their primary purposes differ, with Dexabion focusing more on things like pain, numbness, and muscle problems, and Dolo Neurobion emphasizing pain relief in neurologically-related conditions. It’s essential to note that Dolo Neurobion injection is safer but you should consult with a healthcare professional to determine the most suitable option based on individual health needs.

Storage Recommendations for Dexabion

Keep Dexabion in a cool, dry place with the box tightly closed, ensuring the temperature does not exceed 30°C. Protect it from direct sunlight, maintain the original packaging for added defense, and store it in a dry environment to prevent moisture absorption.


Joan David-Leonhard

Joan David Leonhard is a recent Pharm.D graduate with a strong passion for the pharmaceutical industry and a particular interest in pharmaceutical media and communication. Her brief internship experience includes roles in pharmacy where she built strong patient-pharmacist relationships and a pharmaceutical media internship where she actively contributed to drug information articles, blog posts, social media engagement, and various media projects.
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