Common Supplements To Avoid During Benzo Withdrawal

Benzodiazepines, commonly prescribed for conditions like anxiety, insomnia, and seizures, are known for their fast-acting calming effects. However, the prolonged use of these medications can lead to physical dependence, making withdrawal a challenging and complex process. Individuals undergoing benzodiazepine withdrawal often seek ways to alleviate symptoms and support their recovery.

While supplements can be beneficial in certain situations, there are some that should be approached with caution during benzodiazepine withdrawal. In this article, we will explore the intricacies of benzodiazepine withdrawal, the role of supplements, and those that may be best avoided.

What is Benzodiazepine Withdrawal?

Benzodiazepine withdrawal is characterized by a range of symptoms that can be both physically and mentally taxing. Common withdrawal symptoms include anxiety, insomnia, irritability, muscle stiffness, and even seizures. The severity and duration of withdrawal symptoms can vary depending on factors such as the duration of benzodiazepine use, the specific medication used, and individual differences in metabolism.

One challenge in benzodiazepine withdrawal is the risk of rebound symptoms. As the body adjusts to the absence of the drug, symptoms that the medication was initially prescribed to treat may return with increased intensity. This can contribute to the difficulty of withdrawal and make it crucial for individuals to seek appropriate support and guidance.

The Role of Supplements in Benzodiazepine Withdrawal

Many individuals undergoing benzodiazepine withdrawal turn to supplements as a way to manage symptoms and support their overall well-being. However, it’s essential to approach supplementation with caution, as certain substances may interact with the withdrawal process or even exacerbate symptoms.

1.        Melatonin: Approach with Caution

Melatonin, a hormone that regulates sleep-wake cycles, is commonly used as a natural sleep aid. During benzodiazepine withdrawal, sleep disturbances are a prevalent issue. While melatonin supplementation may seem like a logical solution, caution is advised. Benzodiazepines influence the GABAergic system, and sudden changes in this system during withdrawal can lead to unpredictable reactions to melatonin. It is advisable to consult with a healthcare professional before introducing melatonin during benzodiazepine withdrawal.

2.        Valerian Root: Use with Care

Valerian root is an herbal supplement often used for its calming and sleep-inducing effects. Some individuals may find relief from anxiety and insomnia by incorporating valerian root into their routine. However, caution is warranted, as valerian root interacts with the GABA system, which benzodiazepines also influence. The combined effects may lead to excessive sedation or unexpected reactions. Consulting a healthcare professional before using valerian root during benzodiazepine withdrawal is crucial.

3.        St. John’s Wort: Potential for Interaction

St. John’s Wort is a popular herbal remedy for depression, and some individuals consider using it during benzodiazepine withdrawal to address mood-related symptoms. However, St. John’s Wort is known to interact with various medications, including those that act on the central nervous system. This interaction could potentially lead to adverse effects and should be avoided or approached with caution. Always consult with a healthcare provider before incorporating St. John’s Wort into your regimen during benzodiazepine withdrawal.

4.        Passionflower: Use with Caution

Passionflower is another herbal supplement known for its calming effects. While it is generally considered safe, caution is advised during benzodiazepine withdrawal. The sedative properties of passionflower could potentiate the central nervous system depression associated with benzodiazepine withdrawal. As with other supplements, it is advisable to consult with a healthcare professional before using passionflower during withdrawal.

5.        Omega-3 Fatty Acids: A Potentially Beneficial Addition

Omega-3 fatty acids, found in fish oil and flaxseed oil, have been studied for their potential benefits in mental health. Some research suggests that omega-3 supplementation may have a positive impact on mood and cognitive function. While omega-3 fatty acids are generally considered safe, it is advisable to consult with a healthcare professional before incorporating them into a withdrawal regimen, as individual responses can vary.

6.        Vitamin B Complex: Support for Nervous System Health

The B-vitamin complex, including B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin), plays a crucial role in nervous system function. Deficiencies in these vitamins can contribute to symptoms such as anxiety and insomnia. While a well-balanced diet should provide sufficient B-vitamins, supplementation may be considered under the guidance of a healthcare professional. However, excessive doses of certain B-vitamins can lead to adverse effects, and their use during benzodiazepine withdrawal should be monitored closely.


Benzodiazepine withdrawal is a challenging process that requires careful management and support. While supplements can play a role in alleviating symptoms and promoting overall well-being, it’s crucial to approach them with caution. Certain supplements, such as melatonin, valerian root, St. John’s Wort, and passionflower, may interact with the withdrawal process and should be used under the guidance of a healthcare professional.

Individuals undergoing benzodiazepine withdrawal should prioritize open communication with their healthcare providers to ensure a comprehensive and personalized approach to their withdrawal journey. The decision to use supplements should be made in collaboration with a healthcare professional who can consider the individual’s medical history, the specific benzodiazepine involved, and the overall withdrawal plan.

In conclusion, while supplements can be valuable tools in managing benzodiazepine withdrawal, a cautious and informed approach is essential to ensure their effectiveness and safety in the context of this complex and challenging process.


Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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