Drugs Q & A

Why Does Midol Make Me Feel High?

Midol is a well-known over-the-counter medication primarily designed to alleviate the symptoms associated with menstrual discomfort, such as cramps, bloating, and headaches. It is specifically formulated to provide relief to individuals experiencing the physical and emotional challenges of menstruation.

While Midol is intended to address these symptoms, some users report experiencing sensations of feeling “high” or altered in some way when taking this medication. In this article, we will explore the reasons behind these effects, the ingredients that might contribute to such sensations and the importance of understanding how Midol works in the body.

Understanding Midol’s Composition

Midol, with its different variants catering to various menstrual symptoms, presents a comprehensive approach to relieving discomfort. Understanding the specific active ingredients in Midol can shed more light on why some individuals may feel “high” after taking it:

1.        Acetaminophen: This component is a widely used pain reliever found in many over-the-counter medications. In Midol, acetaminophen plays a crucial role in reducing menstrual cramps and discomfort. It works by interfering with pain signals in the brain and reducing fever. However, it’s important to note that acetaminophen, when taken in excessive doses, can be harmful to the liver. When combined with other ingredients in Midol, particularly caffeine, it can lead to a complex interplay of sensations.

2.        Caffeine: Caffeine is a potent stimulant present in Midol. It’s the same compound found in coffee and energy drinks. Caffeine can have a variety of effects on the body, including increasing alertness, improving concentration, and reducing the perception of fatigue. In Midol, caffeine is added to help combat the tiredness and bloating often experienced during menstruation. The stimulating effects of caffeine can be a contributing factor to the sensation of feeling “high” when taking Midol, especially for individuals who are sensitive to or not accustomed to its effects.

3.        Antihistamines: Midol typically contains Pyrilamine maleate an antihistamine. In Midol, pyrilamine maleate helps fight fatigue and bloating. However, studies have shown that this ingredient can cause euphoria which becomes pronounced when combined with caffeine, contributing to the sensation of feeling “high.”

The Interaction of Ingredients

One of the primary reasons some individuals may feel “high” or altered after taking Midol lies in the interaction of its ingredients, especially caffeine and pyrilamine maleate. Here’s how these components work together:

1.        Caffeine: As a stimulant, caffeine is known for its ability to increase alertness and energy levels. When combined with the relief provided by acetaminophen and antihistamines, the caffeine can lead to a sense of heightened alertness and well-being, which some users may interpret as feeling “high” or more energetic.

2.        Antihistamines: Certain antihistamines like pyrilamine maleate used in Midol can induce euphoria. This can be intensified when combined with caffeine, potentially leading to sensations of being “high” or somewhat disoriented.

The Importance of Dosage and Tolerance

The intensity of these sensations often depends on several factors, including the dosage taken, an individual’s tolerance, and the presence of any underlying medical conditions. If a person takes a higher-than-recommended dosage of Midol or has a low tolerance to caffeine or antihistamines, the chances of feeling “high” or experiencing other unexpected effects can increase.

The Potential for Misuse

Feeling “high” or altered when taking Midol is generally not the intended outcome, and it’s crucial to use the medication as directed. Misusing or abusing Midol by taking excessive doses can lead to a range of adverse side effects, including jitteriness, rapid heart rate, nausea, and dizziness. It can also be harmful to your health.

What to do if Midol is making you high?

If you are experiencing sensations of feeling “high” or altered after taking Midol, it’s important to address the situation responsibly and promptly. Here’s what to do if you believe Midol is affecting you in an unexpected or uncomfortable manner:

1.        Stop Taking Midol: If you suspect that Midol is causing you to feel “high” or if you are experiencing any other unusual effects, cease taking the medication immediately. Do not take any more doses until you have sought guidance from a healthcare professional.

2.        Stay Calm and Hydrated: Keep yourself well-hydrated by drinking water. Staying hydrated can help mitigate some of the side effects you might be experiencing and ensure that you remain comfortable.

3.        Seek Medical Advice: Contact a healthcare professional, such as your primary care physician or a nurse helpline, and describe your symptoms and concerns. They can provide guidance and help assess the situation. If you have any underlying health conditions or are taking other medications, be sure to inform them of these as well.

4.        Avoid Stimulants: While you are feeling “high,” avoid consuming any additional stimulants, such as caffeine, as they can intensify the sensations.

5.        Rest and Monitor: If you are feeling disoriented or drowsy, find a safe and comfortable place to rest until the effects wear off. It’s advisable to have someone stay with you for support and safety, if possible.

6.        Don’t Drive or Operate Machinery: Do not engage in activities that require full alertness, such as driving or operating heavy machinery, while you are experiencing these effects.

7.        Time and Patience: In most cases, the sensations will gradually subside as the medication is metabolized by your body. Be patient and give it time.

8.        Follow Medical Advice: Follow any recommendations or advice provided by your healthcare professional. They may suggest additional steps or treatments to manage the situation.

It’s important to use Midol as directed and to consult with a healthcare professional if you have concerns about its effects or if you experience unexpected sensations. While the “high” feeling may be uncomfortable, it is typically a result of the interaction of the medication’s active ingredients, especially caffeine and antihistamines. Responsible use and seeking guidance from a healthcare professional can help ensure your well-being and comfort during this time.


While some individuals may experience sensations of feeling “high” after taking Midol, these effects are typically a result of the interaction between its active ingredients, especially caffeine and pyrilamine maleate. It’s important to use Midol as directed and not misuse the medication, as doing so can lead to unintended and potentially harmful consequences. If you have concerns about the effects of Midol or any medication, it is advisable to consult with a healthcare professional for guidance and personalized recommendations on managing menstrual discomfort while maintaining your overall well-being. READ Pamprin vs. Midol: Differences, Similarities, Which is Better?

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