Rasburicase Mechanism of Action (MOA)

Rasburicase (Elitek) is an injectable medication used to treat high levels of uric acid (a natural substance that builds up in the blood as tumors break down) in people with certain types of cancer who are being treated with chemotherapy medications

Urate oxidase is known to be present in many mammals but does not naturally occur in humans. Rasburicase is produced by a genetically modified Saccharomyces cerevisiae strain. The complementary DNA (cDNA) coding for rasburicase was cloned from a strain of Aspergillus flavus.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

How Rasburicase works

Rasburicase injection is in a class of medications called enzymes. It works by breaking down uric acid so that the body can eliminate it. In humans, uric acid is the final step in the catabolic pathway of purines. Rasburicase catalyzes enzymatic oxidation of poorly soluble uric acid into an inactive and more soluble metabolite allantoin with carbon dioxide and hydrogen peroxide as byproducts in the chemical reaction.

How long does Rasburicase take to work?

The measurement of plasma uric acid was used to evaluate the effectiveness of rasburicase in clinical studies. Following administration of either 0.15 or 0.20 mg/kg rasburicase daily for up to 5 days, plasma uric acid levels decreased within 4 hours and were maintained below 7.5 mg/dL in 98% of adult and 90% of pediatric patients for at least 7 days. There was no evidence of a dose response effect on uric acid control for doses between 0.15 and 0.20 mg/kg rasburicase.

How should this medicine be used?

Rasburicase injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a hospital or clinic. It is usually given over a period of 30 minutes once a day for up to 5 days. This medication is given as a single course of treatment that will not be repeated.

What special precautions should I follow?

Before receiving rasburicase injection,

•        tell your doctor and pharmacist if you are allergic to rasburicase, any other medications, or any of the ingredients in rasburicase injection. Ask your pharmacist for a list of the ingredients.

•        tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

•        in addition to the condition mentioned in the IMPORTANT WARNING section, tell your doctor if you have or have ever had any other medical conditions.

•        tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving rasburicase injection, call your doctor.

•        if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving rasburicase injection.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What are the side effects of Rasburicase?

Rasburicase may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

•        nausea

•        vomiting

•        constipation

•        diarrhea

•        stomach pain

•        mouth sores

•        throat pain

•        fever

•        headache

•        anxiety

•        join pain

•        swelling of the hands, feet, ankles, or lower legs

•        pain, redness, swelling, or tenderness at the injection site.

Rasburicase injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).


Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
Back to top button

Adblock Detected

Please consider supporting us by disabling your ad blocker