Natrise Tablet: Uses, Dosage, Side Effects, Interactions

Natrise tablet is a brand of Tolvaptan a prescription medicine used to treat hyponatremia (low levels of sodium in the blood) in people who have heart failure (a condition in which the heart cannot pump enough blood to all parts of the body), syndrome of inappropriate antidiuretic hormone (SIADH; a condition in which the body produces too much of a certain natural substance that causes the body to retain water) or other conditions. Natrise tablet is manufactured by Sun Pharmaceutical Industries Ltd.

How does Natrise work?

Natrise Tablet (Tolvaptan) is in a class of medications called vasopressin V2 receptor antagonists. It works by increasing the amount of water released from the body as urine. Removing fluid from the body helps to increase the level of sodium in the blood. This increases urine production, decreases blood water content, and raises blood sodium levels.

How should I take Natrise?

Natrise comes as a tablet to take by mouth. It is usually taken once a day with or without food for no longer than 30 days. At the beginning of your treatment, you will be given Natrise tablet at a regularly scheduled time in the hospital. If you are told to take Natrise tablet at home after you are discharged, you should take it at around the same time every day.

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Natrise tablet exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of Natrise tablet and gradually increase your dose, not more often than once every 24 hours.

Talk to your doctor about what you should do after you stop taking Natrise tablet. You will probably need to limit the amount of fluid you drink, and your doctor will monitor you carefully during this time.

What will happen if I take an excess of Natrise Tablet?

You may require immediate medical attention. Call your doctor or go to a nearby hospital for emergency care. Tolvaptan overdose symptoms include thirst, dry and flaky skin, sunken eyes, rapid heartbeat, rapid and shallow breathing, extremely low blood pressure, passing more urine than usual, and fainting.

For how long do I need to take a Natrise Tablet?

Natrise Tablet is used to lower sodium levels in the blood. Natrise Tablet should not be taken for more than 30 days, even if the doctor has prescribed the dose and duration. After consulting with a doctor, it is possible to discontinue the treatment once the sodium levels have returned to normal.

Does Natrise Tablet affect the sugar levels in the blood?

Yes, Natrise Tablet can cause an increase in blood sugar levels. As a result, patients with diabetes mellitus should exercise extreme caution when taking Natrise Tablet and should monitor their blood sugar levels on a regular basis.

Who should not take Natrise Tablet?

Natrise Tablet should not be taken if you have low sodium levels, are unable to replace fluids through drinking, are unable to tell when you are thirsty, dizzy, or feeling faint, or if your kidneys are not working properly due to excessive fluid loss. You should also avoid Natrise Tablet if your body is unable to produce urine, if you are allergic to Natrise Tablet, or if you are taking certain medications that interfere with Natrise Tablet’s effectiveness.

What are the side effects of Natrise tablet?

Natrise tablets may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • thirst
  • dry mouth
  • frequent, excessive urination
  • constipation

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • loss of appetite
  • nausea
  • vomiting
  • fever
  • feeling unwell
  • unusual tiredness or weakness
  • itching
  • yellowing of the skin or eyes
  • dark urine
  • pain in the upper right part of the stomach
  • diarrhea
  • inability to drink normally
  • dizziness
  • faintness
  • vomit that is bloody or looks like coffee grounds
  • bloody or black and tarry stools
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • hoarseness
  • hives
  • rash

Natrise tablets may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

What drugs can interact with Natrise tablet?

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

A product that may interact with this drug is: desmopressin.

Other medications can affect the removal of Natrise tablet from your body, which may affect how Natrise tablet works. Examples include azole antifungals (such as ketoconazole, itraconazole), boceprevir, cobicistat, HIV protease inhibitors (such as lopinavir, ritonavir), macrolide antibiotics (such as clarithromycin, erythromycin), ribociclib, rifamycins (such as rifabutin, rifampin), St. John’s wort, drugs used to treat seizures (such as carbamazepine, phenytoin), telaprevir, among others.

Can I have grapefruit juice while taking Natrise Tablet?

No, grapefruit or grapefruit juice should not be consumed while taking Natrise Tablet. The reason for this is that grapefruit or grapefruit juice may raise Natrise Tablet levels in your blood, causing your sodium levels to rise too quickly.

Is Natrise safe?

Natrise Tablet is not harmful to patients with kidney disease. There is no need to adjust the Natrise Tablet dosage. Natrise Tablet, on the other hand, is not recommended for patients with severe kidney disease.


Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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