Drugs Q & A

Does Espiride Help With Milk Production?

Milk production in women, known as lactation, is a remarkable biological process primarily associated with nurturing and feeding infants. Hormonal changes during pregnancy and after childbirth trigger this process. Prolactin, produced by the pituitary gland, stimulates milk production in the mammary glands, and oxytocin is released in response to the baby’s suckling, facilitating milk ejection.

Initially, colostrum is produced, providing essential nutrients and antibodies to the newborn. Over time, the composition of breast milk evolves to meet the baby’s nutritional needs. The quantity of milk produced depends on the baby’s demand, maternal well-being, and other factors.

However, inadequate milk production is a concern that some breastfeeding mothers may experience. This can be due to various factors that include insufficient glandular tissue in the breasts, hormonal imbalances, stress, inadequate nutrition, certain medications, or medical conditions.

What is espiride used for ?

Espiride, a brand of Sulpiride (Dogmatil) is a medication belonging to the atypical antipsychotic class, although it has sometimes been categorized as a typical antipsychotic. Its primary medical applications include the management of psychosis associated with schizophrenia and major depressive disorder. It is also utilized, albeit in low doses, for the treatment of anxiety and mild depression. This medication is commonly used in various regions, including Asia, Central America, Europe, South Africa, and South America. Levosulpiride, a purified form of Sulpiride, serves a similar purpose and is available in India. Notably, Sulpiride is not approved for use in the United States, Canada, or Australia. It shares chemical and clinical similarities with another antipsychotic, amisulpride.

Espiride is primarily employed in managing the symptoms of schizophrenia. It serves as both a standalone treatment and an adjunctive therapy for cases of treatment-resistant schizophrenia. Additionally, it has been used in the treatment of dysthymia. While the evidence is of low quality, some studies suggest that Espiride may hasten the antidepressant response in individuals with major depressive disorder. There is also documented efficacy in the treatment of panic disorder. In certain countries, Sulpiride is approved for managing vertigo. Notably, in Japan, Sulpiride has received approval for use in the treatment of both schizophrenia and major depressive disorder at low doses.

Does Espiride help with milk production?

Yes, Espiride contains sulpiride known to have the potential to increase serum prolactin levels, which are associated with milk production. Some studies have shown that it may be effective in increasing milk volume in mothers with documented low milk production, particularly during the postpartum period. It seems to be more effective in preventing the need for supplementation in mothers with no initial milk production. However, the clinical value of sulpiride in enhancing milk supply remains a topic of debate.

Sulpiride is excreted into breast milk, and its concentration in breast milk can be relatively high, which may raise concerns about its impact on breastfeeding infants. Some studies reported no adverse effects in breastfed infants whose mothers took sulpiride as a galactagogue, but others suggested that it could increase serum prolactin in breastfed infants.

Sulpiride may have side effects, such as tiredness, headache, and leg edema, in nursing mothers. It should be used with caution in women with a history of major depression, as it can potentially cause depression as a side effect.

Does Espiride work immediately?

Espiride can potentially increase milk production in breastfeeding women. However, its effectiveness can vary from person to person, and it may not work immediately for everyone. Some women may notice an increase in milk supply relatively quickly after starting the medication, while others may take more time to see a significant change.

The time it takes for Espiride to have an effect on milk production can depend on several factors, including the individual’s response to the medication, the dosage prescribed, and the underlying causes of low milk supply. In some cases, it may take a few days to a couple of weeks for a noticeable improvement in milk supply.

How to take Espiride for breastfeeding

Espiride (Sulpiride) is not officially approved as a medication for increasing milk supply, and its use for this purpose is considered off-label. If a healthcare provider decides to prescribe it to a breastfeeding mother to potentially enhance milk production, it should only be used under their guidance and supervision. How to take Espiride in the context of breastfeeding:

1.        Consult Your Healthcare Provider: Before considering Espiride as a galactagogue, it’s essential to have a thorough discussion with your healthcare provider. They will evaluate your specific situation, including your breastfeeding concerns, medical history, and other factors that may be influencing your milk supply.

2.        Follow the Prescribed Dosage: If your healthcare provider decides that Espiride may be appropriate for you, they will provide you with a prescription and specific instructions regarding the dosage. It’s crucial to adhere to the prescribed dose and schedule, and not to exceed it.

3.        Monitor for Side Effects: Keep a close eye on any potential side effects or adverse reactions. Common side effects may include tiredness, headaches, and leg edema. If you experience any unusual or severe side effects, contact your healthcare provider promptly.

4.        Breastfeed on Demand: Continue breastfeeding your baby on demand or according to their feeding schedule. While Espiride may help increase milk production, the act of breastfeeding itself plays a significant role in stimulating milk supply.

5.        Evaluate Progress: Regularly communicate with your healthcare provider to assess the effectiveness of Espiride in enhancing milk production. If you are not seeing the desired results or experience any issues, they may need to adjust the treatment plan.

6.        Consider Other Factors: Keep in mind that medication should not replace other essential aspects of breastfeeding success, such as proper breastfeeding technique, adequate hydration, and a balanced diet. Make sure to address these factors as well.

7.        Be Cautious About Prolonged Use: Espiride should not be used for extended periods, as it can have potential side effects, such as depression. Your healthcare provider will guide you on the appropriate duration of treatment.

8.        Be Informed: Educate yourself about the potential benefits and risks associated with Espiride use during breastfeeding, and ask your healthcare provider any questions or concerns you may have.

If Espiride is prescribed by a healthcare provider to address low milk supply, it should only be used as directed and monitored closely. It’s essential to maintain open communication with your healthcare provider and prioritize overall breastfeeding best practices, such as proper technique and frequency, for a successful breastfeeding experience.

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Dr Chinenye Otorkpa

Dr. Chinenye Otorkpa is a Family Physician with a passion for women and children's well-being. She holds a Master's degree in International Public health from Liverpool John Moores University and an active membership in the World Association of Family Physicians (WONCA). She combines her medical expertise and global network connections to provide holistic healthcare.
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