Doxi: Side Effects, Dosage, Uses, and Review
Doxi is a brand of doxycycline hyclate, a medication in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. It works to treat rosacea by decreasing the inflammation that causes this condition.
Doxi is used to treat infections caused by bacteria, including pneumonia and other respiratory tract infections; certain infections of the skin or eye; infections of the lymphatic, intestinal, genital, and urinary systems; and certain other infections that are spread by ticks, lice, mites, infected animals, or contaminated food and water. It is also used along with other medications to treat acne. Doxi is also used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack), in people who may have been exposed to anthrax in the air, and to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It is also used to prevent malaria. Doxi can also be used in people who cannot be treated with penicillin to treat certain types of food poisoning.
Before taking doxycycline,
- tell your doctor and pharmacist if you are allergic to doxycycline, minocycline, tetracycline, demeclocycline, any other medications, sulfites, or any of the ingredients in doxycycline capsules, extended-release capsules, tablets, extended-release tablets, or suspension. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: acitretin (Soriatane); anticoagulants (‘blood thinners’) such as warfarin (Coumadin, Jantoven); barbiturates such as butabarbital (Butisol), phenobarbital, and secobarbital (Seconal); bismuth subsalicylate; carbamazepine (Epitol, Tegretol, others); isotretinoin (Absorica, Amnesteem, Clavaris, Myorisan, Zenatane); penicillin; phenytoin (Dilantin, Phenytek); and proton pump inhibitors such as dexlansoprazole (Dexilant), esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid, in Prevpac), omeprazole (Prilosec, in Yosprala, Zegerid), pantoprazole (Protonix), and rabeprazole (Aciphex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- be aware that antacids containing magnesium, aluminum, or calcium, calcium supplements, iron products, and laxatives containing magnesium interfere with Doxi, making it less effective. Take doxycycline 2 hours before or 6 hours after taking antacids, calcium supplements, and laxatives containing magnesium. Take Doxi 2 hours before or 4 hours after iron preparations and vitamin products that contain iron.
- tell your doctor if you have or have ever had lupus (condition in which the immune system attacks many tissues and organs including the skin, joints, blood, and kidneys), intracranial hypertension (pseudotumor cerebri; high pressure in the skull that may cause headaches, blurry or double vision, vision loss, and other symptoms), a yeast infection in your mouth or vagina, surgery on your stomach, asthma, or kidney or liver disease.
- you should know that Doxi may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, or injections). Talk to your doctor about using another form of birth control.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking Doxi, call your doctor immediately. Doxi can harm the fetus.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Doxi may make your skin sensitive to sunlight. Tell your doctor right away if you get a sunburn.
- you should know that when you are receiving doxycycline for prevention of malaria, you should also use protective measures such as effective insect repellent, mosquito nets, clothing covering the whole body, and staying in well-screened areas, especially from early nighttime until dawn. Taking doxycycline does not give you full protection against malaria.
- you should know that when doxycycline is used during pregnancy or in babies or children up to 8 years of age, it can cause the teeth to become permanently stained. Doxi should not be used in children under 8 years of age except for inhalational anthrax, Rocky Mountain spotted fever, or if your doctor decides it is needed.
How to use Doxi Film Tablet
Read the Patient Information Leaflet if available from your pharmacist before you start taking doxycycline and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
This medication is best taken by mouth on an empty stomach, at least 1 hour before or 2 hours after a meal, usually 1 or 2 times daily or as directed by your doctor. Take this medication with a full glass of water (8 ounces/240 milliliters) unless directed otherwise. If stomach upset occurs, taking it with food or milk may help. However, Doxi may not work as well if you take it with food or milk (or anything high in calcium), so ask your doctor or pharmacist if you may take it that way. Do not lie down for at least 10 minutes after taking this medication.
Take this medication 2 to 3 hours before or after taking any products containing aluminum, calcium, iron, magnesium, zinc, or bismuth subsalicylate. Some examples include antacids, didanosine solution, quinapril, vitamins/minerals, dairy products (such as milk, yogurt), and calcium-enriched juice. These products bind with Doxi, preventing your body from fully absorbing the drug.
When using to prevent malaria, this medication is usually taken once daily. Take the first dose of this medication 1 to 2 days before travel or as directed by your doctor. Continue to take this medication daily while in the malarious area. Upon returning home, you should keep taking this medication for 4 more weeks. If you are unable to finish this course of Doxi, contact your doctor.
If you are using the liquid form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
The dosage is based on your medical condition and response to treatment. For children, the dosage may also be based on weight.
For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.
Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.
Tell your doctor if your condition persists or worsens.
What are the side effects of Doxi?
Get emergency medical help if you have any signs of an allergic reaction to Doxi: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using Doxi.
Call your doctor at once if you have:
- severe stomach pain, diarrhea that is watery or bloody;
- throat irritation, trouble swallowing;
- chest pain, irregular heart rhythm, feeling short of breath;
- little or no urination;
- low white blood cell counts – fever, chills, swollen glands, body aches, weakness, pale skin, easy bruising or bleeding;
- severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;
- loss of appetite, upper stomach pain (that may spread to your back), tiredness, nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).
Common Doxi side effects may include:
- nausea, vomiting, upset stomach, loss of appetite;
- mild diarrhea;
- skin rash or itching;
- darkened skin color; or
- vaginal itching or discharge.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.