Drugs Q & A

Does Taking Saxenda At Night Help With Nausea?

Saxenda is a brand name for the medication liraglutide. It is an injectable prescription medication used for weight management in adults who have obesity or are overweight and have at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol.

Liraglutide belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. It works by mimicking the action of a hormone called GLP-1, which helps regulate appetite and food intake. Saxenda can help reduce calorie intake by making you feel fuller and less hungry.

When using Saxenda, it is typically prescribed as part of a comprehensive weight management program that includes a reduced-calorie diet and increased physical activity. The medication is self-administered once daily via subcutaneous injection (under the skin), usually in the abdomen, thigh, or upper arm.

It’s important to note that Saxenda is not a standalone solution for weight loss. It should be used in conjunction with lifestyle changes to achieve and maintain a healthier weight. Additionally, Saxenda is not suitable for everyone, and Nausea is a common side effect associated with Saxenda use.

Saxenda-induced nausea often manifests as a queasy or uneasy feeling in the stomach, accompanied by a sense of discomfort or unease. It may be accompanied by an urge to vomit, feelings of an upset stomach, increased salivation, sweating, and a loss of appetite. Nausea can vary in intensity and may be accompanied by other symptoms such as dizziness or lightheadedness.

During clinical trials, a significant number of individuals experienced nausea while taking Saxenda. In fact, nausea is one of the most frequently reported adverse reactions. In this article, we shall be taking a good look at the timing of Saxenda administration and Nausea.

How to take Saxenda

Saxenda is an injectable medication that comes in a pre-filled pen. Here is a general guideline on how to take Saxenda:

1.      Get familiar with the pen: Read the instructions provided by the manufacturer and become familiar with the Saxenda pen. The pen contains a pre-filled cartridge of medication and a needle for injection.

2.      Choose an injection site: Select an injection site, typically the abdomen (at least 2 inches away from the belly button), thigh, or upper arm. Clean the area with an alcohol swab and let it dry.

3.      Prepare the pen: Remove the cap from the Saxenda pen. Check the medication in the cartridge. It should be clear and colorless. Do not use the pen if the medication appears discolored or if there are particles in it.

4.      Set the dose: Turn the dose selector on the pen to the prescribed dose. Your healthcare provider will determine the appropriate starting dose and any subsequent dose adjustments. The pen may need to be primed before the first use, following the manufacturer’s instructions.

5.      Inject the medication: Hold the pen at a 90-degree angle to your skin and pinch the injection site. Insert the needle fully into the skin and press the injection button to deliver the medication. Keep the button pressed for about 6 seconds to ensure the full dose is administered.

6.      Remove the needle and dispose of it properly: After injecting, withdraw the needle from your skin. Place the pen cap back on and dispose of the used needle in a sharps container as per local guidelines.

7.      Store the pen: Store the Saxenda pen in the refrigerator between uses, but do not freeze it. If needed, you can carry the pen with you at room temperature for up to 30 days.

It’s important to follow your healthcare provider’s instructions on how to take Saxenda, including dosing, injection technique, and any specific recommendations they may provide.

Does taking Saxenda at night help with nausea?

Yes, taking Saxenda (liraglutide) at night may help alleviate nausea for some individuals. Since nausea is a common side effect of Saxenda, adjusting the timing of the medication may be a strategy to manage this symptom. Some people find that taking Saxenda before bed allows them to sleep through any potential nausea, as the body adjusts to the medication overnight.

However, it’s important to note that the timing of Saxenda should be discussed with your healthcare provider. They will consider factors such as your individual needs, medication regimen, and any other medications or health conditions you may have. Your healthcare provider may have specific recommendations on when to take Saxenda based on your situation.

It’s worth mentioning that while taking Saxenda at night may be beneficial for some individuals, it doesn’t guarantee that it will completely eliminate nausea for everyone. If you are experiencing persistent or severe nausea while taking Saxenda, it’s important to communicate this to your healthcare provider. They can provide personalized advice and guidance on managing the side effects and may suggest alternative strategies or adjustments to your Saxenda regimen.

Here are some tips to help manage nausea while taking Saxenda:

1.      Start with a lower dose: Your healthcare provider may start you on a lower dose of Saxenda and gradually increase it over time. Starting with a lower dose can help your body adjust and potentially reduce nausea.

2.      Take Saxenda with food: Some individuals find that taking Saxenda with a meal or shortly after eating can help reduce nausea. However, it’s important to follow your healthcare provider’s instructions regarding timing and dosing.

3.      Stay hydrated: Ensure that you are drinking enough water throughout the day. Staying hydrated may help alleviate nausea symptoms.

4.      Eat smaller, more frequent meals: Consuming smaller, more frequent meals rather than large meals can help ease nausea. Avoiding greasy or spicy foods that can aggravate stomach discomfort may also be helpful.

5.      Avoid triggers: Pay attention to any specific triggers that may exacerbate your nausea, such as certain foods or smells, and try to avoid them while taking Saxenda.

6.      Consider anti-nausea medication: In some cases, your healthcare provider may recommend taking over-the-counter or prescription anti-nausea medication to help manage nausea associated with Saxenda. It’s important to discuss this option with your healthcare provider before starting any new medication.

7.      Allow time for adjustment: Nausea is often a temporary side effect that may subside as your body adjusts to Saxenda. Give yourself time to adapt, and if nausea persists or becomes severe, consult your healthcare provider for further guidance.

Remember, everyone’s experience with Saxenda can be different, and what works for one person may not work for another. It’s crucial to communicate any concerns or side effects with your healthcare provider so that they can provide personalized advice and determine the best course of action for you.


Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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