Drugs Q & A

Can You Take Tylenol With Mucinex?

Mixing any combination of prescription drugs, over-the-counter drugs can be unpredictable and dangerous.  Most fatal overdoses involve the use of more than one type of drug (poly-drug use).

Poly-drug use is dangerous because different drugs act on our bodies in different ways. The harmful effects are magnified by using more than one drug type. For example, the more alcohol in the body, the less heroin needed to cause an overdose.

What is Tylenol?

Tylenol also known as acetaminophen is a medication that relieves mild-to-moderate pain, headache, and fever. You can use acetaminophen to relieve mild or moderate pain. This is usually pain from colds, sore throats, headaches, body or muscle aches, menstrual cramps, arthritis, or toothaches. You can also use it to reduce fever.

It’s not fully known how acetaminophen works. It doesn’t reduce swelling or inflammation. Instead, it’s thought that it blocks the release of certain chemicals in your brain that signal the sensation of pain.

What is Mucinex?

Mucinex is a brand of guaifenesin, an expectorant used for the temporary relief of coughs caused by the common cold, bronchitis, and other breathing illnesses. This product is usually not used for ongoing cough from smoking or long-term breathing problems (such as chronic bronchitis, emphysema) unless directed by your doctor. Guaifenesin is an expectorant. It works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier. 

Can you take Tylenol with Mucinex?

There are no interactions between Mucinex and Tylenol. Guaifenesin has no known severe, serious, moderate, or mild interactions with other drugs. This does not necessarily mean no interactions exist. Always consult your healthcare provider before using Tylenol with Mucinex together.

How should I take Tylenol?

Take only one product that contains acetaminophen at a time. Acetaminophen is in many products and you could accidentally take too much if you’re using more than one product at the same time. Acetaminophen can be used by all age groups in recommended doses.

Children (general): The dose of acetaminophen for children is based on body size. Usually, it is calculated as 10 mg to 15 mg per kilogram of body weight, every 4 to 6 hours. No more than 65 mg/kg should be given in a 24-hour period. Children should not take more than 5 doses in 24 hours unless advised by a doctor. For children under 6 months of age, consult a doctor.

Children’s liquid medications should be given using a calibrated dosing device, such as an oral syringe. This ensures that you are giving your child the right amount. Some formulations of liquid acetaminophen contain different concentrations of acetaminophen. Pay careful attention to the concentration on the label and the calculated dose volume.

Adults: The dose of acetaminophen for adults is 325 mg to 650 mg every 4 to 6 hours. Do not take more than 4,000 mg in a 24-hour period. If you are taking the extended-release caplets, the recommended dose for adults and children over 12 years is 1300 mg taken every 8 hours.

Acetaminophen products available without a prescription should not be used for longer than 5 days in a row for pain or 3 days in a row for fever. If you consume 3 or more alcoholic drinks in a day, do not take acetaminophen products, as your risk of liver damage is increased.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without talking to your doctor. Always take acetaminophen exactly as prescribed by your doctor.

How should I take Mucinex?
Dosage form: tablet, extended-release

  • do not crush, chew, or break tablet
  • take with a full glass of water
  • this product can be administered without regard for the timing of meals
  • adults and children 12 years of age and over: 1 or 2 tablets every 12 hours. Do not exceed 4 tablets in 24 hours.
  • children under 12 years of age: do not use.

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