Drugs Q & A

Why Was Uribel Discontinued?

Uribel is a prescription medication that is used to relieve the symptoms of urinary tract irritation and discomfort, including pain, burning, urgency, and frequency. The drug is a combination of methenamine, sodium phosphate monobasic, phenyl salicylate, and hyoscyamine sulfate. Uribel is produced by a company called Acella Pharmaceuticals, LLC.

The history of Uribel can be traced back to the early 20th century when hyoscyamine sulfate was first introduced as a treatment for a variety of urinary tract disorders. Over time, other ingredients, such as methenamine, sodium phosphate monobasic, and phenyl salicylate, were added to create a more comprehensive treatment option.

Uribel was first approved by the U.S. Food and Drug Administration (FDA) in 1981 for the treatment of urinary tract irritation and discomfort. Since then, it has become a popular medication among healthcare professionals and patients alike. In 2014, Acella Pharmaceuticals acquired the rights to Uribel, and it remains a widely prescribed medication to this day.

Uribel is available in capsule form and is typically taken orally, although some patients may be instructed to open the capsules and mix the contents with water. The medication is generally well-tolerated, although some patients may experience side effects, such as dizziness, drowsiness, dry mouth, blurred vision, or difficulty urinating.

Has Uribel Been Discontinued?

No, Uribel has not been discontinued and the medication is still on the market. However, Uribel can have potential side effects and safety concerns that should be considered before taking it.

The most common side effects of Uribel include nausea, vomiting, upset stomach, dizziness, headache, and a blue or green discoloration of the urine. These side effects are usually mild and go away on their own, but if they persist or become severe, it is important to speak with a healthcare provider.

In rare cases, Uribel can cause more serious side effects, such as allergic reactions, difficulty breathing, or liver problems. If you experience any of these symptoms, seek immediate medical attention.

It is also important to note that Uribel should not be taken by individuals who are allergic to any of its components or by those with certain medical conditions, such as liver disease or a history of kidney stones. Additionally, Uribel may interact with other medications, so it is important to inform your healthcare provider of any medications you are currently taking before starting Uribel.

Does Uribel affect the kidneys?

Yes, this is one of the concerns about Uribel is its potential effect on the kidneys. The medication contains sodium phosphate monobasic, which can increase the risk of kidney problems, especially in patients with a history of kidney disease or other risk factors.

Therefore, Uribel should be used with caution in patients with kidney disease or a history of kidney problems. Your doctor may need to adjust the dose of the medication or monitor your kidney function regularly while you are taking Uribel.

Additionally, Uribel can cause a temporary discoloration of urine, turning it blue or green. This is a harmless side effect of the medication and does not indicate any problems with kidney function.

It is important to discuss any concerns or questions about Uribel with your healthcare provider, who can help determine if it is the right medication for you and monitor for any potential side effects or complications.

Does Uribel heal the bladder?

No, Uribel does not heal the bladder. Uribel is a medication used to treat the symptoms of painful or difficult urination, urinary urgency, and urinary frequency associated with certain bladder conditions such as urinary tract infections, bladder spasms, and interstitial cystitis.

Uribel works by combining three different medications: methenamine, sodium salicylate, and hyoscyamine sulfate. Methenamine is converted to formaldehyde in the urine, which helps to kill bacteria that may be causing bladder symptoms. Sodium salicylate is a pain reliever and fever reducer, while hyoscyamine sulfate helps to relax the muscles in the bladder, reducing spasms and discomfort.

While Uribel can provide relief from symptoms, it does not treat the underlying condition causing the symptoms. Therefore, it is important to see a healthcare provider for a proper diagnosis and treatment plan for any bladder condition.

What are the long-term side effects of Uribel?

While Uribel is generally considered safe and effective, like any medication, it can have potential long-term side effects.

Some potential long-term side effects of Uribel may include:

1.      Kidney damage: High doses of Uribel over long periods of time can potentially cause kidney damage or worsening of existing kidney problems.

2.      Increased risk of infection: Chronic use of Uribel can lead to an increased risk of urinary tract infections and other infections.

3.      Gastrointestinal problems: Uribel can cause gastrointestinal problems such as nausea, vomiting, and constipation, especially with long-term use.

4.      Allergic reactions: Some individuals may have an allergic reaction to one or more of the ingredients in Uribel, which can cause symptoms such as hives, itching, and difficulty breathing.

5.      Interactions with other medications: Uribel can interact with other medications, potentially causing harmful side effects. Patients should always inform their healthcare provider of all medications they are taking, including over-the-counter drugs, supplements, and herbal remedies.

It is important to note that not everyone who takes Uribel will experience long-term side effects, and the risk of side effects may vary depending on individual factors such as age, overall health, and other medications being taken. Patients who have concerns about the potential long-term side effects of Uribel should speak with their healthcare provider.

Uribel alternatives

There are several alternatives to Uribel for the treatment of urinary tract symptoms. These include:

1.      AZO: AZO is an over-the-counter medication that can help relieve urinary tract symptoms such as pain, burning, and urgency. It contains phenazopyridine, which works by numbing the urinary tract lining.

2.      Pyridium: Pyridium is another medication that can help relieve urinary tract symptoms such as pain, burning, and urgency. It contains phenazopyridine, which works by numbing the urinary tract lining.

3.      Cystex: Cystex is an over-the-counter medication that can help relieve urinary tract symptoms such as pain, burning, and urgency. It contains methenamine and sodium salicylate, which work together to help prevent and treat urinary tract infections.

4.      Cranberry juice: Cranberry juice is a natural remedy that may help prevent and treat urinary tract infections. It contains compounds that can prevent bacteria from sticking to the urinary tract lining.

5.      D-mannose: D-mannose is a natural remedy that may help prevent and treat urinary tract infections. It works by preventing bacteria from sticking to the urinary tract lining.

It is important to consult with a healthcare provider before starting any new medication or natural remedy for urinary tract symptoms.

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Dr. Oche Otorkpa PG Cert, MPH, PhD

Dr. Oche is a seasoned Public Health specialist who holds a post graduate certificate in Pharmacology and Therapeutics, an MPH, and a PhD both from Texila American University. He is a member of the International Society of Substance Use Professionals and a Fellow of the Royal Society for Public Health in the UK. He authored two books: "The Unseen Terrorist," published by AuthorHouse UK, and "The Night Before I Killed Addiction."
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