Drugs Q & A

PLIVA 433 Pills: Frequently Asked Questions (FAQ)

What is the pill PLIVA 433 used for?

The white PLIVA 433 supplied by Major Pharmaceuticals contains Trazodone Hydrochloride 50 mg an antidepressant used to treat major depressive disorder.

PLIVA 433 belongs to a group of drugs called serotonin receptor antagonists and reuptake inhibitors (SARIs). While PLIVA 433 is not a true member of the selective serotonin reuptake inhibitors (SSRIs) class of antidepressants, it does still share many properties of the SSRIs.

PLIVA 433 works by helping to restore the balance of a certain natural chemical (serotonin) in the brain. PLIVA 433 may help to improve your mood, appetite, and energy level as well as decrease anxiety and insomnia related to depression.



  • 100 Tablets/BottleNDC# 50111-0560-01
  • 500 Tablets/BottleNDC# 50111-0560-02
  • 1000 Tablets/BottleNDC# 50111-0560-03

Is PLIVA 433 a sleeping pill?

PLIVA 433 isn’t a sleeping pill and isn’t approved to treat insomnia. It’s used to treat depression and one of the side effects is drowsiness. There aren’t enough studies to show that PLIVA 433 should be used for sleep. Talk to your provider about other options if this is a concern for you.

How long does it take PLIVA 433 to work?

Some people will see improvement in mood within 1 to 4 weeks of taking PLIVA 433, but it can take a couple of months to feel its full effects. It’s possible to have side effects from PLIVA 433 before you see an improvement in your mood.

Is PLIVA 433 the same as alprazolam (Xanax)?

No. You might experience some of the same side effects while taking alprazolam (Xanax) or PLIVA 433, but the two medications belong to different medication classes. PLIVA 433 is a selective serotonin reuptake inhibitor (SSRI), while alprazolam (Xanax) is a benzodiazepine. They work on different chemicals in your brain to change your mood or behavior.

Can I drink alcohol while taking PLIVA 433?

While studies don’t show that PLIVA 433 raises the risk of the side effects of alcohol (e.g., drowsiness, mental alertness, coordination), it’s still not recommended to combine alcohol and PLIVA 433 in a person who has depression. Alcohol is considered a depressant and therefore can worsen some of the symptoms of depression.

Is PLIVA 433 safe to take while pregnant?

Taking PLIVA 433 in the third trimester of pregnancy can be harmful to your unborn baby. Babies may be born with movement disorders or withdrawal symptoms. There is a National Pregnancy Registry for Psychiatric Medications to monitor the safety of certain medications during pregnancy. If you are currently pregnant and taking PLIVA 433, it’s encouraged that you enroll in the registry.

What side effects should I expect while taking PLIVA 433 pill?

Some of the common side effects of PLIVA 433 pill are:

o          Headache

o          Nausea

o          Vomiting

o          Diarrhea

o          Constipation

o          Weakness

o          Nervousness

o          Dizziness

o          Muscle Pain

o          Rash

o          Sweating

o          Itchy eyes

•  Some of the serious side effects of PLIVA 433 pill are:

o          Chest pain

o          Irregular heartbeat

o          Loss of consciousness

o          Fainting

o          Seizures

o          Shortness of breath

•  If you have any of these serious symptoms immediately contact your doctor for further assistance. In any case, due to PLIVA 433 pill if you get any kind of reaction on your body stop the medication and contact your doctor.

•  A doctor advised you to take the medicines after evaluating your problems and considered that the benefits of this medicine are greater than the side effects. The majority of the people who use this medicine don’t show any side effects. Get medical help immediately if you get any serious PLIVA 433 pill side effects.


•  Before taking PLIVA 433 pill, talk with your doctor if you are allergic to it or any other medications. The product may contain some inactive ingredients which can cause some serious problems. Before using PLIVA 433 pill, talk with your doctor if you are having any medical history:

o          Bipolar disorders

o          Suicide attempts

o          Heart disease

o          Liver disease

o          Kidney disease

o          Blood pressure

o          Glaucoma.

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