List of Drugs That Cause Hypersexuality

Hypersexuality also known as compulsive sexual behavior or sexual addiction is an excessive preoccupation with sexual fantasies, urges or behaviors that is difficult to control, causes you distress, or negatively affects your health, job, relationships or other parts of your life.

Recent psychiatric literature has used the term “hypersexuality” to denote pathologically increased sexual behavior. Various patterns of increased sexuality have been described in people, including sexuality that is excessive, developmentally precocious, compulsive, aggressive, or otherwise socially inappropriate. However, according to the American Psychiatric Association, hypersexuality is not a formal diagnosis because there is a lack of evidence to show that it is a health condition rather than a set of symptoms.

Can drugs or medication cause hypersexuality?

Yes, medications and illicit drugs can cause hypersexuality. A report published in the Journal of Clinical Psychopharmacology, discussed the first documented case of a female patient who experienced a venlafaxine-associated increase in libido which required therapy change for her depression and anxiety. Studies indicate that approximately 40–50% of male stimulant users and 20–30% of female users experience aphrodisiac effects from cocaine or methamphetamine.

Reasons for this gender discrepancy are unknown. Once the link between sex and drug abuse and dependence has been established, sexual activity of any kind can become a strong relapse trigger for stimulant use. Similarly, drug use can trigger a return to drug-related hypersexual behaviors. It can be very hard to break out of this “reciprocal relapse” pattern in which one addictive behavior reliably leads to engaging in the other behavior.

List of Drugs That Cause Hypersexuality

Legal medications and illicit drugs can cause hypersexuality, the list of drugs that cause hypersexuality include:

Aripiprazole: Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is primarily used in the treatment of schizophrenia and bipolar disorder. Aripiprazole can enhance sexual desire in patients with schizophrenia. The drugs dopaminergic agonistic effects at the mesolimbic circuit especially at nucleus accumbens may be responsible for hypersexuality phenomenon.

Vyvanse: Lisdexamfetamine, sold under the brand name Vyvanse among others, is a medication that is a derivative of amphetamine. It is mainly used to treat attention deficit hyperactivity disorder in people over the age of five as well as moderate-to-severe binge eating disorder in adults. A known side effect of amphetamines including Vyvanse is hypersexuality, the consumption of stimulants may lead to hypersexuality and excessive masturbation.

Mephedrone: Mephedrone is a recent designer drug, commonly referred to as bath salts, and is one of the most popular recreationally used new psychoactive substances. Like MDMA, it shares similarities with stimulants and with hallucinogens, and psychopharmacological research indicates that it is similar to stimulant drugs, such as amphetamines. Studies indicate that mephedrone use results in such typical stimulant-related subjective effects as the intensification of sensory experiences and sexual arousal.

Cocaine: Cocaine is a tropane alkaloid and stimulant drug obtained primarily from the leaves of two coca species, Erythroxylum coca and Erythroxylum novogranatense. It is most commonly used as a recreational drug and euphoriant. Available evidence reveals that cocaine prolongs sexual arousal or cause spontaneous erections and orgasms. As a result, people who use cocaine often report an increased sex drive in addition to the more standard cocaine effects, such as euphoria, confidence, and increased energy. This strong desire for intimacy can lead to impulsiveness and poor decision-making.

Methamphetamine: Methamphetamine is a powerful, highly addictive stimulant that affects the central nervous system. It takes the form of a white, odorless, bitter-tasting crystalline powder that easily dissolves in water or alcohol. Methamphetamine was developed early in the 20th century from its parent drug, amphetamine, and was used originally in nasal decongestants and bronchial inhalers. Methamphetamine users report having heightened sexual pleasure, numerous sexual partners and engaging in unprotected sex due to loss of inhibitory control. This compulsive sexual behavior contributes to increased prevalence of sexually transmitted infections, but the neural basis for this is unknown.

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