AN 627 pill is a brand of Tramadol 50 mg supplied by Amneal Pharmaceuticals. Tramadol is a prescription drug and belongs to the drug class narcotic analgesics . This pill is a controlled substance. This means it can only be used with a doctor’s close supervision.
How quickly it takes the pain relieving effect of AN 627 pill to kick in can be affected by whether the drug is combined with another pain relieving medication, such as a nonsteroidal anti-inflammatory drug. AN 627 pill should not be taken with other opioid medications.
When you take AN 627 pill and it is absorbed into the bloodstream, you get a gradual onset of pain relief, that then reaches a peak, before the pain relieving effect tapers off.
- Fast-acting tramadol peaks in your system after 2 to 3 hours, and typically lasts around 6 hours. It’s taken every 4 to 6 hours as needed for pain.
- The extended-release version peaks at 10 to 12 hours, but generally provides lasting pain relief for up to 24 hours. It’s taken once daily.
Food doesn’t affect how AN 627 pill is absorbed, so you can take it with or without food. But AN 627 pill does have to be taken in its original form. It cannot be split, chewed or crushed. It also shouldn’t be dissolved.
- For fast-acting tramadol, the recommended limit is 400 mg per day. A starting dose is 25 mg or 50 mg. After titration, 50 mg to 100 mg may be taken as needed for pain relief every 4 to 6 hours.
- For extended-release tramadol, the recommended limit is 300 mg per day. It’s taken once daily and comes in three different strengths: 100 mg, 200 mg and 300 mg.
When you first start taking AN 627 pill, a lower dose is prescribed and then slowly raised every few days until the optimal dose is found. People who have kidney disease, liver disease or are over 75 years old may need to take lower doses of tramadol.
When you’re in pain, it can be hard to wait for a medication to take effect, but it’s very important not to take more AN 627 pill than prescribed.
Serious FDA warnings
This drug has boxed warnings from the FDA about possible dangerous effects:
- Addiction and misuse
- Slowed or stopped breathing
- Accidental ingestion
- Life-threatening effects for children
- Neonatal opioid withdrawal syndrome
- Interactions with certain drugs
- Interactions with benzodiazepines
Addiction and misuse: This drug can lead to addiction and misuse, which can result in overdose and death. To help avoid these problems, take this drug exactly as prescribed by your doctor. If you have any concerns about this warning, talk with your doctor.
Slowed or stopped breathing: This drug can slow or stop your breathing. If this isn’t treated immediately, it can cause death. This risk is highest within three days of starting the drug or increasing your dosage.
Accidental ingestion: If anyone, especially children, takes a dose of this drug by accident even once, it can cause death. This drug should be stored out of reach of children.
Life-threatening effects for children: In some cases, children’s bodies can process this drug too quickly. This can lead to slowed breathing and death. This drug shouldn’t be used in children younger than 12 years of age. It should also not be used in children younger than 18 years of age who have certain risk factors, or who have just had a tonsillectomy or adenoidectomy.
Neonatal opioid withdrawal syndrome: If you use this medication for a long time while you’re pregnant, it can cause withdrawal in your baby. Withdrawal in your baby can lead to death. Symptoms of withdrawal can include irritability, hyperactivity, unusual sleep patterns, and a high-pitched cry. They can also include tremor, vomiting, diarrhea, and failure to gain weight.
Interactions with certain drugs: Taking tramadol with certain drugs can cause varied serious effects. These effects include increased tramadol levels, possibly leading to seizures and serotonin syndrome. They also include reduced effectiveness of tramadol, and opioid withdrawal symptoms. The drugs that can cause these effects include amiodarone, quinidine, erythromycin, ketoconazole, ritonavir, and similar medications.
Interactions with benzodiazepines: Taking tramadol with benzodiazepines and other similar drugs can cause very serious effects. These effects can include severe fatigue, slowed breathing, coma, and death.