Medicines

Doxibion: Uses, Benefits, Dosage, Side Effects, Interactions

Doxibion is a combination medicine containing Doxylamine Succinate, Pyridoxine Hydrochloride, and  Folic Acid. Doxibion is used for the treatment of vomiting and nausea associated with pregnancy in women who do not respond to conservative management.

Doxibion is also used to relieve symptoms of allergy, hay fever, and the common cold. This medication works by blocking certain natural substances (histamine, acetylcholine) that your body makes. This effect helps to relieve allergy, and cold symptoms such as watery eyes, runny nose, and sneezing.

 It also helps to treat or prevent vitamin B6 deficiency. It is also used to treat a certain type of anemia (lack of red blood cells).

Each tablet of Doxibion contains the following active ingredients: Doxylamine Succinate 20 mg, Pyridoxine Hydrochloride 20 mg & Folic Acid 5 mg.

How it works

The Doxylamine Succinate in Doxibion reduces nausea and vomiting by inhibiting histaminergic signaling to the vomiting center in the medulla.

Pyridoxine (vitamin B6) is a vitamin. It is given because a lack of pyridoxine in the body may also be a factor in causing nausea and vomiting during pregnancy.

The folic acid in Doxibion works by restoring the levels of vitamin B6 in the body and treats nausea and vomiting during pregnancy. Folic acid is also a form of vitamin B which can provide essential nutrients during pregnancy. You should take this medicine exactly as prescribed by the doctor.

In synergy, these three active ingredients work to prevent nausea and vomiting in pregnancy. In a clinical study, morning sickness symptoms improved after 2 weeks of taking this combination. These symptoms included how many times the participants vomited and how long they felt nauseous.

Warnings

Do not use Doxibion if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Before taking this medicine

Do not use Doxibion if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use this medicine if you are allergic to doxylamine or pyridoxine, or to other antihistamines such as Benadryl or Dramamine.

Tell your doctor if you have ever had:

•        asthma or other breathing disorder;

•        glaucoma, increased pressure inside your eye;

•        blockage in your digestive tract (stomach or intestines);

•        a stomach ulcer; or

•        bladder obstruction or other urination problems.

You should not breastfeed while using Doxibion.

Doxibion is not approved for use by anyone younger than 18 years old.

How should I take Doxibion?

Doxibion comes as a tablet to take by mouth. It is usually taken on an empty stomach (at least 1 hour before or 2 hours after a meal) with a full glass of water. At first, your doctor will usually tell you to take it once a day at bedtime.

If your symptoms of nausea and vomiting are not better, then your doctor may tell you to take the Doxibion tablet two or three times a day, or the extended-release tablet two times a day.

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Doxibion exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What happens if I overdose?

Symptoms of overdose may include the following:

  • a build-up of fluid in the body
  • confusion
  • dark red or cola-colored urine
  • difficulty urinating or painful urination
  • dilated pupils (black circles in the centers of the eyes)
  • dizziness
  • drowsiness or sleepiness
  • dry mouth
  • fast, irregular, or pounding heartbeat
  • muscle pain or weakness
  • restlessness
  • seizures

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take more than the prescribed dose in a day. Do not take a double dose of Doxibion to make up for a missed one.

What are the possible side effects of Doxibion?

The most common side effects of Doxibion include:

•        anxiety,

•        bloating,

•        blurred vision,

•        constipation,

•        diarrhea,

•        difficulty urinating,

•        dizziness,

•        drowsiness,

•        fast heart rate,

•        fatigue,

•        headache,

•        irritability,

•        itching, and

•        malaise,

•        nightmares,

•        numbness and tingling,

•        palpitations,

•        rash

•        shortness of breath,

•        sleepiness,

•        stomach upset,

•        trouble sleeping (insomnia),

•        vertigo,

Tell the doctor if you have any side effect that bothers you or that does not go away.

Doxibion may cause serious side effects including:

•        confusion,

•        easy bruising or bleeding,

•        fast or irregular heartbeat,

•        irritability,

•        itching,

•        mood changes,

•        nervousness,

•        rash,

•        severe dizziness, and

•        swelling of the face, tongue, or throat,

•        trouble breathing

•        trouble urinating,

Get medical help right away, if you have any of the symptoms listed above.

These are not all the possible side effects of Doxibion. For more information, ask your doctor or pharmacist.

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